USP5

Gene Symbol	USP5
Entrez Gene	8078
Alt Symbol	ISOT
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 5 (isopeptidase T)
Other Description	deubiquitinating enzyme 5|isopeptidase T|ubiquitin carboxyl-terminal hydrolase 5|ubiquitin isopeptidase T|ubiquitin specific protease 5 (isopeptidase T)|ubiquitin thioesterase 5|ubiquitin thiolesterase 5|ubiquitin-specific protease-5 (ubiquitin isopeptidase T)|ubiquitin-specific-processing protease 5
Swissprots	D3DUS7 D3DUS8 Q96J22 P45974
Accessions	AAB51314 AAB51315 EAW88724 EAW88725 EAW88726 EAW88727 P45974 AI289395 AK308021 AU099996 BC004889 AAH04889 BC005139 AAH05139 CN276110 DQ893030 ABM83956 DQ896274 ABM87273 U35116 AAA78934 U47927 AAC50465 X91349 CAA62690 XR_931526 XR_931527 NM_001098536 NP_001092006 NM_003481 NP_003472
Function	Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. {ECO:0000269|PubMed:19098288}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human USP5 full length protein - ab198421 from Abcam Category Protein Prices $1,187.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Active rabbit USP5 full length protein - ab188683 from Abcam Category Protein Prices $253.00 Sizes 10 µg Source Native Species Rabbit

Human USP5 full length protein - ab132451 from Abcam Category Protein Source Wheat germ Species Human

Human USP5 protein fragment - ab127223 from Abcam Category Protein Source E. coli Species Human

USP5 protein (Human) - Chemical Free - ab80732 from Abcam Category Protein Source E. coli Species Human

USP5 Antibody Blocking Peptide - LS-E6881 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Isopeptidase T/USP5 Recombinant Protein - H00008078-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Isopeptidase T/USP5 Protein - H00008078-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Isopeptidase T/USP5 Protein - NBP1-99464 from Novus Biologicals Category Protein Prices $205.00 Sizes 25 µg Source E. coli Species Human

Recombinant Human Isopeptidase T/USP5 Protein - NBP1-99463 from Novus Biologicals Category Protein Prices $205.00 Sizes 25 µg Source E. coli Species Human

Isopeptidase T/USP5 Peptide - P0923 from Novus Biologicals Category Peptide Species Human

USP5-Antibody-C-term-Blocking-Peptide - BP2134b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Isopeptidase T/USP5, CF - E-322-025 from R&D Systems Category Protein Source E. coli-derived,

Rabbit Isopeptidase T/USP5, CF - E-320-010 from R&D Systems Category Protein Source Rabbit erythrocytes,

Rabbit Isopeptidase T/USP5, CF - E-320-025 from R&D Systems Category Protein Source Rabbit erythrocytes,

Human USP5 His tag protein - orb84535 from Biorbyt Category Protein Prices $196.00, $238.00, $298.00 Sizes 20 μg, 50 μg, 100 μg Source Insect Species Human

Isopeptidase T protein (long form) - 30R-2739 from Fitzgerald Category Protein Prices $295.00 Sizes 25 µg Source E.coli Species Human

Isopeptidase T protein (short form) - 30R-2738 from Fitzgerald Category Protein Prices $295.00 Sizes 25 µg Source E.coli Species Human

USP5 / ISOT - H00008078-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP5 / ISOT - H00008078-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

USP5 / ISOT - H00008078-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP5 / ISOT - H00008078-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

USP5 fusion protein - Ag0770 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

USP5 fusion protein - Ag7575 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

USP5 fusion protein - ag7252 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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