USP5

Gene Symbol	USP5
Entrez Gene	8078
Alt Symbol	ISOT
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 5 (isopeptidase T)
Other Description	deubiquitinating enzyme 5|isopeptidase T|ubiquitin carboxyl-terminal hydrolase 5|ubiquitin isopeptidase T|ubiquitin specific protease 5 (isopeptidase T)|ubiquitin thioesterase 5|ubiquitin thiolesterase 5|ubiquitin-specific protease-5 (ubiquitin isopeptidase T)|ubiquitin-specific-processing protease 5
Swissprots	D3DUS7 D3DUS8 Q96J22 P45974
Accessions	AAB51314 AAB51315 EAW88724 EAW88725 EAW88726 EAW88727 P45974 AI289395 AK308021 AU099996 BC004889 AAH04889 BC005139 AAH05139 CN276110 DQ893030 ABM83956 DQ896274 ABM87273 U35116 AAA78934 U47927 AAC50465 X91349 CAA62690 XR_931526 XR_931527 NM_001098536 NP_001092006 NM_003481 NP_003472
Function	Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. {ECO:0000269|PubMed:19098288}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP5 overexpression lysate - LY418652 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

USP5 overexpression lysate - LY420633 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

USP5 overexpression lysate - LY426027 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

USP5 293 Cell Lysate - 408707 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Isopeptidase T/USP5 Overexpression Lysate (Native) - NBL1-17669 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

USP5 Over-expression Lysate Product - GWB-886E17 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human USP5 / ISOT Insect Cell Lysate (WB positive control) - 12772-H08BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human USP5 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175062 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human USP5 Knockdown Stable Cell Line - CSC-DC017193 from Creative biogene Category Cell Line Species Human

Search more