USP5

Gene Symbol	USP5
Entrez Gene	8078
Alt Symbol	ISOT
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 5 (isopeptidase T)
Other Description	deubiquitinating enzyme 5|isopeptidase T|ubiquitin carboxyl-terminal hydrolase 5|ubiquitin isopeptidase T|ubiquitin specific protease 5 (isopeptidase T)|ubiquitin thioesterase 5|ubiquitin thiolesterase 5|ubiquitin-specific protease-5 (ubiquitin isopeptidase T)|ubiquitin-specific-processing protease 5
Swissprots	D3DUS7 D3DUS8 Q96J22 P45974
Accessions	AAB51314 AAB51315 EAW88724 EAW88725 EAW88726 EAW88727 P45974 AI289395 AK308021 AU099996 BC004889 AAH04889 BC005139 AAH05139 CN276110 DQ893030 ABM83956 DQ896274 ABM87273 U35116 AAA78934 U47927 AAC50465 X91349 CAA62690 XR_931526 XR_931527 NM_001098536 NP_001092006 NM_003481 NP_003472
Function	Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. {ECO:0000269|PubMed:19098288}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP5 CRISPR/Cas9 KO Plasmid (h) - sc-404293 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP5 HDR Plasmid (h) - sc-404293-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP5 Double Nickase Plasmid (h) - sc-404293-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP5 Double Nickase Plasmid (h2) - sc-404293-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP5 CRISPR Activation Plasmid (h) - sc-404293-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP5 CRISPR Activation Plasmid (h2) - sc-404293-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP5 Lentiviral Activation Particles (h) - sc-404293-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP5 Lentiviral Activation Particles (h2) - sc-404293-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP5 siRNA (h) - sc-76869 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP5 shRNA Plasmid (h) - sc-76869-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP5 shRNA (h) Lentiviral Particles - sc-76869-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Isopeptidase T/USP5 RNAi - H00008078-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Isopeptidase T/USP5 RNAi - H00008078-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU025811 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22599 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22599 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05125 from Sigma-Aldrich Category miRNA

USP5 siRNA (Human) - CRH5359 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

USP5 - MBS8215091 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human USP5 (NM_003481.2) - SHH441712 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human USP5(NM_003481.2) - SHL118722 from Creative biogene Category siRNA Species Reactivities Human

Human USP5 siRNA - orb265861 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

USP5 shRNA Plasmid (Human) - CHH5359 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

USP5 miRNA 3'UTR clone - MiUTR1H-11070 from Creative biogene Species Reactivities Human

USP5 miRNA 3'UTR clone - MiUTR3H-04129 from Creative biogene Species Reactivities Human

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