| Gene Symbol |
USP5
|
| Entrez Gene |
8078
|
| Alt Symbol |
ISOT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 5 (isopeptidase T)
|
| Other Description |
deubiquitinating enzyme 5|isopeptidase T|ubiquitin carboxyl-terminal hydrolase 5|ubiquitin isopeptidase T|ubiquitin specific protease 5 (isopeptidase T)|ubiquitin thioesterase 5|ubiquitin thiolesterase 5|ubiquitin-specific protease-5 (ubiquitin isopeptidase T)|ubiquitin-specific-processing protease 5
|
| Swissprots |
D3DUS7 D3DUS8 Q96J22 P45974
|
| Accessions |
AAB51314 AAB51315 EAW88724 EAW88725 EAW88726 EAW88727 P45974 AI289395 AK308021 AU099996 BC004889 AAH04889 BC005139 AAH05139 CN276110 DQ893030 ABM83956 DQ896274 ABM87273 U35116 AAA78934 U47927 AAC50465 X91349 CAA62690 XR_931526 XR_931527 NM_001098536 NP_001092006 NM_003481 NP_003472
|
| Function |
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. {ECO:0000269|PubMed:19098288}.
|