PKP2

Gene Symbol PKP2
Entrez Gene 5318
Alt Symbol ARVD9
Species Human
Gene Type protein-coding
Description plakophilin 2
Other Description plakophilin-2
Swissprots B8QFA1 B8QGS7 Q99959 B8QGS6 D3DUW9 Q99960 A0AV37 Q4VC01
Accessions ACD03459 EAW88511 EAW88512 EAW88513 EAW88514 EAW88515 EAW88516 Q99959 AK299139 BAG61191 AU125826 AW439621 BC070083 BC094762 AAH94762 BC126199 AAI26200 BC143966 AAI43967 BC143967 BX956935 DB454360 EU520483 ACD13292 EU520484 ACD13293 EU520485 ACD13294 EU520486 ACD13295 HQ258660 ADR83411 X97675 CAA66264 NM_001005242 NP_001005242 NM_004572 NP_004563
Function May play a role in junctional plaques. {ECO:0000269|PubMed:22781308}.
Subcellular Location Nucleus {ECO:0000269|PubMed:22781308}. Cell junction, desmosome {ECO:0000269|PubMed:22781308}. Note=Nuclear and associated with desmosomes.
Tissue Specificity Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata. {ECO:0000269|PubMed:10374264, ECO:0000269|PubMed:22781308}.
Top Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC)

plakophilin 2 (C-1) - sc-393711 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
plakophilin 2 (C-1): sc-393711. Western blot analysis of plakophilin 2 expression in non-transfected: sc-117752 (A) and human plakophilin 2 transfected: sc-372976 (B) 293T whole cell lysates and HeLa nuclear extract (C).

plakophilin 2 (A-20) - sc-18976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

plakophilin 2 (C-17) - sc-18977 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

plakophilin 2 (H-125) - sc-367018 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

plakophilin 2 (28) - sc-136039 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
plakophilin 2 (28): sc-136039. Western blot analysis of plakophilin 2 expression in Hep G2 whole cell lysate.

Anti-Plakophilin 2 antibody - ab187182 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab187182. Blue DAPI for nuclear staining.

Anti-Plakophilin 2 antibody - ab74671 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Plakophilin 2 antibody (ab74671) at 1/500 dilutionLane 1 : extracts from HeLa cellsLane 2 : extracts from HepG2 cellsLane 3 : extracts from HeLa cells with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Plakophilin 2 antibody [8H6] - ab151402 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8H6
Overlay histogram showing HeLa cells stained with ab151402 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab151402, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Plakophilin 2 antibody - C-terminal - ab187766 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (C-Terminus, clone PP2-62,86,150) - LS-C85371 from LifeSpan Bioscience

Prices $515.00
Sizes 5 ml
Host Mouse
Clonality Monoclonal
Clone PP2-62,86,150

Anti-PKP2 / Plakophilin 2 Antibody - LS-C193790 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µl
Host Guinea Pig
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (aa527-872, clone Pkp2-518) - LS-C193448 from LifeSpan Bioscience

Prices $435.00
Sizes 5 ml
Host Mouse
Clonality Monoclonal
Clone Pkp2-518

Anti-PKP2 / Plakophilin 2 Antibody (aa837-866, FITC) - LS-C266441 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (aa837-866, Azide-free, HRP) - LS-C266443 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (aa837-866, PE) - LS-C266444 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (aa837-866, APC) - LS-C284618 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (aa837-866, Biotin) - LS-C284620 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (aa837-866, AP) - LS-C284619 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (aa632-681) - LS-C120222 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa/HepG2 cells, using PKP2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-PKP2 / Plakophilin 2 Antibody (aa837-866) - LS-C324077 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody - LS-C341278 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PKP2 / Plakophilin 2 Antibody (aa143-192) - LS-C107909 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PKP2 / Plakophilin 2 antibody LS-C107909 Western blot of COLO205 cell lysate.

Anti-PKP2 / Plakophilin 2 Antibody (Pro663) - LS-C177485 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Plakophilin 2 (P663) pAb in extracts from HeLa cells.

Anti-PKP2 / Plakophilin 2 Antibody (aa571-849) - LS-C314514 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PKP2 / Plakophilin 2.

Anti-PKP2 / Plakophilin 2 Antibody (aa863-881) - LS-C313369 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of PKP2 / Plakophilin 2 antibody. All lanes: Anti-PKP2 at 0.5ug/ml. Lane 1: Rat Cardiac Muscle Tissue Lysate at 40ug. Lane 2: Human Placenta Tissue Lysate at 40ug. Lane 3: Rat Brain Tissue Lysate at 40ug. Lane 4: Rat Intestine Tissue Lysate at 40ug. Lane 5: HELA Whole Cell Lysate at 40ug. Lane 6: JURKAT Whole Cell Lysate at 40ug. Lane 7: 293T Whole Cell Lysate at 40ug. Lane 8: MCF-7 Whole Cell Lysate at 40ug. Lane 9: U87 Whole Cell Lysate at 40ug. Predicted bind size: 97KD. Observed bind size: 97KD.
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