| Gene Symbol |
ALKBH7
|
| Entrez Gene |
84266
|
| Alt Symbol |
ABH7, SPATA11, UNQ6002
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alkB, alkylation repair homolog 7 (E. coli)
|
| Other Description |
alkylated DNA repair protein alkB homolog 7|alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial|probable alpha-ketoglutarate-dependent dioxygenase ABH7|spermatogenesis associated 11|spermatogenesis cell proliferation related protein|spermatogenesis cell proliferation-related protein|spermatogenesis-associated protein 11
|
| Swissprots |
Q9BT30 B2R4U9 Q53FF3
|
| Accessions |
EAW69102 Q9BT30 AK223336 BAD97056 AK311956 BAG34896 AY358858 AAQ89217 AY427650 AAR24624 BC004393 AAH04393 BM271861 BX334356 XM_005259658 XP_005259715 NM_032306 NP_115682
|
| Function |
May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9D6Z0, ECO:0000269|PubMed:23666923, ECO:0000269|PubMed:25122757}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:23666923}.
|
| Tissue Specificity |
Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta. {ECO:0000269|PubMed:17979886}.
|