ALKBH7

Gene Symbol	ALKBH7
Entrez Gene	84266
Alt Symbol	ABH7, SPATA11, UNQ6002
Species	Human
Gene Type	protein-coding
Description	alkB, alkylation repair homolog 7 (E. coli)
Other Description	alkylated DNA repair protein alkB homolog 7|alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial|probable alpha-ketoglutarate-dependent dioxygenase ABH7|spermatogenesis associated 11|spermatogenesis cell proliferation related protein|spermatogenesis cell proliferation-related protein|spermatogenesis-associated protein 11
Swissprots	Q9BT30 B2R4U9 Q53FF3
Accessions	EAW69102 Q9BT30 AK223336 BAD97056 AK311956 BAG34896 AY358858 AAQ89217 AY427650 AAR24624 BC004393 AAH04393 BM271861 BX334356 XM_005259658 XP_005259715 NM_032306 NP_115682
Function	May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9D6Z0, ECO:0000269|PubMed:23666923, ECO:0000269|PubMed:25122757}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:23666923}.
Tissue Specificity	Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta. {ECO:0000269|PubMed:17979886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALKBH7 full length protein - ab164545 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Recombinant Human ALKBH7 Protein - H00084266-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ALKBH7 / SPATA11 - H00084266-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ALKBH7 / SPATA11 - H00084266-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ALKBH7 fusion protein - Ag7772 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

ALKBH7 fusion protein - ag7624 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ALKBH7, GST-tagged - ALKBH7-9588H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Probable alpha-ketoglutarate-dependent dioxygenase ABH7(ALKBH7) - CSB-YP880097HU CSB-EP880097HU CSB-BP880097HU CSB-MP880097HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ALKBH7 / SPATA11 - TP302583 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (ALKBH7), Recombinant Protein - MBS1487466 from MyBioSource Category Protein Prices $950.00, $950.00, $1,175.00, $1,175.00, $1,420.00, $1,420.00, $1,885.00, $1,885.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ALKBH7 Recombinant Protein Antigen - NBP2-38450PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ALKBH7 Recombinant Protein Antigen - NBP1-81231PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ALKBH7 Peptide, Human - M34GP00517H from Creative Peptides Category Peptide Source Synthetic. Species Human

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