ALKBH7

Gene Symbol ALKBH7
Entrez Gene 84266
Alt Symbol ABH7, SPATA11, UNQ6002
Species Human
Gene Type protein-coding
Description alkB, alkylation repair homolog 7 (E. coli)
Other Description alkylated DNA repair protein alkB homolog 7|alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial|probable alpha-ketoglutarate-dependent dioxygenase ABH7|spermatogenesis associated 11|spermatogenesis cell proliferation related protein|spermatogenesis cell proliferation-related protein|spermatogenesis-associated protein 11
Swissprots Q9BT30 B2R4U9 Q53FF3
Accessions EAW69102 Q9BT30 AK223336 BAD97056 AK311956 BAG34896 AY358858 AAQ89217 AY427650 AAR24624 BC004393 AAH04393 BM271861 BX334356 XM_005259658 XP_005259715 NM_032306 NP_115682
Function May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9D6Z0, ECO:0000269|PubMed:23666923, ECO:0000269|PubMed:25122757}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:23666923}.
Tissue Specificity Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta. {ECO:0000269|PubMed:17979886}.

ALKBH7 CRISPR/Cas9 KO Plasmid (h) - sc-410624 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH7 HDR Plasmid (h) - sc-410624-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH7 Double Nickase Plasmid (h) - sc-410624-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH7 Double Nickase Plasmid (h2) - sc-410624-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH7 CRISPR Activation Plasmid (h) - sc-410624-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH7 CRISPR Activation Plasmid (h2) - sc-410624-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH7 Lentiviral Activation Particles (h) - sc-410624-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH7 Lentiviral Activation Particles (h2) - sc-410624-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALKBH7 siRNA (h) - sc-97190 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ALKBH7 shRNA Plasmid (h) - sc-97190-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ALKBH7 shRNA (h) Lentiviral Particles - sc-97190-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN3072 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3072 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ALKBH7 siRNA (Human) - CRJ3392 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALKBH7 - MBS8200874 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ALKBH7 (NM_032306.3) - SHH235282 from Creative biogene

Category siRNA
Species Reactivities Human

Human ALKBH7 siRNA - orb273893 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALKBH7 shRNA Plasmid (Human) - CHJ3392 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ALKBH7 miRNA 3'UTR clone - MiUTR3H-12830 from Creative biogene

Species Reactivities Human
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