IL18RAP

Gene Symbol	IL18RAP
Entrez Gene	8807
Alt Symbol	ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB
Species	Human
Gene Type	protein-coding
Description	interleukin 18 receptor accessory protein
Other Description	CD218 antigen-like family member B|IL-18 receptor accessory protein|IL-18 receptor beta|cluster of differentiation w218b|interleukin-1 receptor 7|interleukin-18 receptor accessory protein|interleukin-18 receptor beta
Swissprots	B2RPJ3 Q53TT4 O95256 Q3KPE7 Q53TU5 Q3KPE8
Accessions	AAY15049 AAY15080 CCF77059 EAX01791 O95256 AF077346 AAC72196 AK300026 BAG61837 BC069630 AAH69630 BC106764 AAI06765 BC106765 AAI06766 BC137474 AAI37475 BC137475 AAI37476 DN996214 DQ116957 AAZ52551 XM_011512087 XP_011510389 XM_011512088 XP_011510390 XM_011512089 XP_011510391 XR_923052 NM_003853 NP_003844
Function	Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. {ECO:0000250, ECO:0000269|PubMed:9792649}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. {ECO:0000269|PubMed:10925275, ECO:0000269|PubMed:11046021, ECO:0000269|PubMed:9792649}.
Top Pathways	Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL18RAP overexpression lysate - LY418382 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IL18RAP 293 Cell Lysate - 408570 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

IL18RAP Over-expression Lysate Product - GWB-EE0569 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Rhesus IL18RAP HEK293 Cell Lysate (WB positive control) - 90122-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Rhesus

Rhesus IL18RAP HEK293 Cell Lysate (WB positive control) - 90122-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Rhesus

Human IL18RAP / IL1R7 HEK293 Cell Lysate (WB positive control) - 10176-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL18RAP / IL1R7 HEK293 Cell Lysate (WB positive control) - 10176-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

IL-18 R beta/IL-1 R7/ACPL Overexpression Lysate (Native) - NBP2-10544 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IL-18 R beta/IL-1 R7/ACPL Overexpression Lysate (Denatured) - H00008807-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human IL18RAP Knockdown Stable Cell Line - CSC-DC007557 from Creative biogene Category Cell Line Species Human

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