| Gene Symbol |
IL18RAP
|
| Entrez Gene |
8807
|
| Alt Symbol |
ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 18 receptor accessory protein
|
| Other Description |
CD218 antigen-like family member B|IL-18 receptor accessory protein|IL-18 receptor beta|cluster of differentiation w218b|interleukin-1 receptor 7|interleukin-18 receptor accessory protein|interleukin-18 receptor beta
|
| Swissprots |
B2RPJ3 Q53TT4 O95256 Q3KPE7 Q53TU5 Q3KPE8
|
| Accessions |
AAY15049 AAY15080 CCF77059 EAX01791 O95256 AF077346 AAC72196 AK300026 BAG61837 BC069630 AAH69630 BC106764 AAI06765 BC106765 AAI06766 BC137474 AAI37475 BC137475 AAI37476 DN996214 DQ116957 AAZ52551 XM_011512087 XP_011510389 XM_011512088 XP_011510390 XM_011512089 XP_011510391 XR_923052 NM_003853 NP_003844
|
| Function |
Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. {ECO:0000250, ECO:0000269|PubMed:9792649}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. {ECO:0000269|PubMed:10925275, ECO:0000269|PubMed:11046021, ECO:0000269|PubMed:9792649}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD)
|