EZH1

Gene Symbol EZH1
Entrez Gene 2145
Alt Symbol KMT6B
Species Human
Gene Type protein-coding
Description enhancer of zeste 1 polycomb repressive complex 2 subunit
Other Description ENX-2|enhancer of zeste homolog 1|histone-lysine N-methyltransferase EZH1
Swissprots Q92800 B4DSS2 B4DIZ7 A6NCH6 O43287 B4E3R7 B4DIJ1 Q53XP3 Q14459
Accessions EAW60870 EAW60871 Q92800 AB002386 BAA20842 AB004818 BAA25019 AK295626 BAG58503 AK295853 BAG58659 AK299887 BAG61734 AK304835 BAG65579 AK309121 AK310399 AK310556 AK311237 AL833159 BC015882 AAH15882 BT009782 AAP88784 DC333017 L38934 AAB59574 L38938 U50315 AAC50778 XM_005257144 XP_005257201 XM_005257145 XP_005257202 XM_005257146 XP_005257203 XM_011524517 XP_011522819 XM_011524518 XP_011522820 XM_011524519 XP_011522821 NM_001991 NP_001982
Function Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}.
Subcellular Location Nucleus {ECO:0000269|PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.

ENX-2 (C-8) - sc-398767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ENX-2 (C-8): sc-398767. Western blot analysis of ENX-2 expression in non-transfected: sc-117752 (A) and mouse ENX-2 transfected: sc-125300 (B) 293T whole cell lysates.

ENX-2 (H-97) - sc-292275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ENX-2 (C-12) - sc-20349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ENX-2 (C-12): sc-20349. Western blot analysis of ENX-2 expression in non-transfected: sc-117752 (A) and mouse ENX-2 transfected: sc-125300 (B) 293T whole cell lysates.

ENX-2 (N-14) - sc-20347 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ENX-2 (N-14): sc-20347. Western blot analysis of ENX-2 expression in I-11.15 whole cell lysates.

Anti-EZH 1 + 2 antibody [EP1408Y] - ab51605 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1408Y
Anti-EZH 1 + 2 antibody [EP1408Y] (ab51605) at 1/500 dilution + Jurkat cell lysate at 10 µg/mlSecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-EZH1 antibody - ab189833 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of A549 cells using ab189833. Blue DAPI for nuclear staining.

Anti-EZH1 antibody - ab86128 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EZH1 antibody (ab86128) at 1 µg/mlLane 1 : MOLT4 (Human acute lymphoblastic leukemia cell line) Whole Cell Lysate Lane 2 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-EZH1 antibody - ab3670 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-EZH1 antibody (ab3670) at 2 µg/ml + MOLT4 cell lysate (in RIPA buffer) at 35 µg

Anti-EZH1 antibody - ab13665 from Abcam

Prices $378.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot detection of EZH1 in mouse (lane 1) and human (lane 2) spleen lysate using ab13665 at 2 ug/ml.

Anti-EZH1 antibody - N-terminal - ab176115 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Human lung tissue labeling EZH1 with ab176115  at 5 μg/ml dilution.

Anti-EZH1 antibody - N-terminal - ab137693 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-EZH1 antibody - N-terminal (ab137693) at 1/1000 dilution + whole cell lysate prepared from HepG2 cells at 30 µg

Anti-EZH1 / ENX-2 Antibody (C-Terminus) - LS-C345232 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of EZH1 Antibody with human 293T Whole Cell lysate.

Anti-EZH1 / ENX-2 Antibody (Glu192) - LS-C176828 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of ENX-2 (E192) pAb in paraffin-embedded human brain tissue.

Anti-EZH1 / ENX-2 Antibody (aa393-422) - LS-C98476 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with EZH1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-EZH1 / ENX-2 Antibody - LS-C334314 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cell using EZH1 antibody. Blue: DAPI for nuclear staining.

Anti-EZH1 / ENX-2 Antibody (N-Terminus) - LS-C144356 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of EZH1 in human lung tissue with EZH1 antibody at 5 ug/ml.

Anti-EZH1 / ENX-2 Antibody (N-Terminus) IHC-plus™ - LS-B6614 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EZH1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6614 concentration 5 ug/ml.

Anti-EZH1 / ENX-2 Antibody (Internal, AP) - LS-C277276 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EZH1 / ENX-2 Antibody (aa180-229) - LS-C109883 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EZH1 antibody LS-C109883 Western blot of Fetal Brain lysate.

Anti-EZH1 / ENX-2 Antibody (Internal, APC) - LS-C277277 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EZH1 / ENX-2 Antibody - LS-C676 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot detection of EZH1 in mouse (lane 1) and human (lane 2) spleen lysate using antibody at 2 ug/ml.

Anti-EZH1 / ENX-2 Antibody (Internal, Biotin) - LS-C277278 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EZH1 / ENX-2 Antibody (aa171-220) - LS-C119186 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lung carcinoma tissue, using EZH1 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-EZH1 / ENX-2 Antibody (Internal, FITC) - LS-C277279 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EZH1 / ENX-2 Antibody (aa8-20) - LS-C54805 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (2 ug/ml) of MOLT-4 lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
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