| Gene Symbol | EZH1 |
|---|---|
| Entrez Gene | 2145 |
| Alt Symbol | KMT6B |
| Species | Human |
| Gene Type | protein-coding |
| Description | enhancer of zeste 1 polycomb repressive complex 2 subunit |
| Other Description | ENX-2|enhancer of zeste homolog 1|histone-lysine N-methyltransferase EZH1 |
| Swissprots | Q92800 B4DSS2 B4DIZ7 A6NCH6 O43287 B4E3R7 B4DIJ1 Q53XP3 Q14459 |
| Accessions | EAW60870 EAW60871 Q92800 AB002386 BAA20842 AB004818 BAA25019 AK295626 BAG58503 AK295853 BAG58659 AK299887 BAG61734 AK304835 BAG65579 AK309121 AK310399 AK310556 AK311237 AL833159 BC015882 AAH15882 BT009782 AAP88784 DC333017 L38934 AAB59574 L38938 U50315 AAC50778 XM_005257144 XP_005257201 XM_005257145 XP_005257202 XM_005257146 XP_005257203 XM_011524517 XP_011522819 XM_011524518 XP_011522820 XM_011524519 XP_011522821 NM_001991 NP_001982 |
| Function | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3. |
ENX-2 CRISPR/Cas9 KO Plasmid (h) - sc-403611 from Santa Cruz Biotechnology
|
||||||||
ENX-2 HDR Plasmid (h) - sc-403611-HDR from Santa Cruz Biotechnology
|
||||||||
ENX-2 Double Nickase Plasmid (h) - sc-403611-NIC from Santa Cruz Biotechnology
|
||||||||
ENX-2 Double Nickase Plasmid (h2) - sc-403611-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ENX-2 CRISPR Activation Plasmid (h) - sc-403611-ACT from Santa Cruz Biotechnology
|
||||||||
ENX-2 CRISPR Activation Plasmid (h2) - sc-403611-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ENX-2 Lentiviral Activation Particles (h) - sc-403611-LAC from Santa Cruz Biotechnology
|
||||||||
ENX-2 Lentiviral Activation Particles (h2) - sc-403611-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ENX-2 siRNA (h) - sc-38187 from Santa Cruz Biotechnology
|
||||||||
ENX-2 shRNA Plasmid (h) - sc-38187-SH from Santa Cruz Biotechnology
|
||||||||
ENX-2 shRNA (h) Lentiviral Particles - sc-38187-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU051091 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN8066 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8066 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR12873 from Sigma-Aldrich
|
||||||||
EZH1 siRNA (Human) - CRH1490 from Cohesion Biosciences
|
||||||||
EZH1 - MBS8202568 from MyBioSource
|
||||||||
shRNA set against Human EZH1 (NM_001991.3) - SHH288321 from Creative biogene
|
||||||||
Human EZH1 siRNA - orb261992 from Biorbyt
|
||||||||
EZH1 shRNA Plasmid (Human) - CHH1490 from Cohesion Biosciences
|
||||||||
EZH1 miRNA 3'UTR clone - MiUTR4H-TG03222 from Creative biogene
|