EZH1

Gene Symbol	EZH1
Entrez Gene	2145
Alt Symbol	KMT6B
Species	Human
Gene Type	protein-coding
Description	enhancer of zeste 1 polycomb repressive complex 2 subunit
Other Description	ENX-2|enhancer of zeste homolog 1|histone-lysine N-methyltransferase EZH1
Swissprots	Q92800 B4DSS2 B4DIZ7 A6NCH6 O43287 B4E3R7 B4DIJ1 Q53XP3 Q14459
Accessions	EAW60870 EAW60871 Q92800 AB002386 BAA20842 AB004818 BAA25019 AK295626 BAG58503 AK295853 BAG58659 AK299887 BAG61734 AK304835 BAG65579 AK309121 AK310399 AK310556 AK311237 AL833159 BC015882 AAH15882 BT009782 AAP88784 DC333017 L38934 AAB59574 L38938 U50315 AAC50778 XM_005257144 XP_005257201 XM_005257145 XP_005257202 XM_005257146 XP_005257203 XM_011524517 XP_011522819 XM_011524518 XP_011522820 XM_011524519 XP_011522821 NM_001991 NP_001982
Function	Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human EZH1 + EED + SUZ12 full length protein - ab196395 from Abcam Category Protein Prices $1,712.00 Sizes 50 µg Source Baculovirus Species Human

Human EZH1 peptide - ab97927 from Abcam Category Peptide

Human EZH1 peptide - ab22954 from Abcam Category Peptide Species Human

EZH1-Antibody-Center-Blocking-Peptide - BP2511c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EZH1 Peptide - AC21-0287-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

EZH1 control peptide - AP26135CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

EZH1 Peptide - 45-560P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

EZH1 Peptide - 6261P from ProSci Category Peptide Species Human

EZH1 fusion protein - Ag14732 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

EZH1 fusion protein - ag2758 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human EZH1, His-tagged - EZH1-12612H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Enhancer Of Zeste Homolog 1 (EZH1) - RPK072Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Enhancer Of Zeste Homolog 1 (EZH1) - RPK072Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Enhancer Of Zeste Homolog 1 (EZH1) - RPK072Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

EZH1 Blocking Peptide - CBP1404 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Monkey

ENX-2 (E192) Peptide - BS2114P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Enhancer Of Zeste Homolog 1 (EZH1) - RPK072Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Histone-lysine N-methyltransferase EZH1(EZH1) - CSB-YP852913HU CSB-EP852913HU CSB-BP852913HU CSB-MP852913HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EZH1 - TP302367 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

EZH1, Peptide - MBS426612 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Bovine

Recombinant Human EZH1 Complex protein, His-tagged - EZH1-81H from Creative Biomart Category Protein Source Insect cell Species Human

EZH1-Antibody-N-term-Blocking-Peptide - BP2511d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EZH1 peptide - orb217267 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Enhancer Of Zeste Homolog 1 (EZH1) - RPU51236 from Biomatik Category Protein Prices $167.00, $342.00, $523.00, $653.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

EZH1 Recombinant Protein (OPCD00861) - OPCD00861 from Aviva Systems Biology Category Protein Source E.coli Species Human

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