EZH1

Gene Symbol	EZH1
Entrez Gene	2145
Alt Symbol	KMT6B
Species	Human
Gene Type	protein-coding
Description	enhancer of zeste 1 polycomb repressive complex 2 subunit
Other Description	ENX-2|enhancer of zeste homolog 1|histone-lysine N-methyltransferase EZH1
Swissprots	Q92800 B4DSS2 B4DIZ7 A6NCH6 O43287 B4E3R7 B4DIJ1 Q53XP3 Q14459
Accessions	EAW60870 EAW60871 Q92800 AB002386 BAA20842 AB004818 BAA25019 AK295626 BAG58503 AK295853 BAG58659 AK299887 BAG61734 AK304835 BAG65579 AK309121 AK310399 AK310556 AK311237 AL833159 BC015882 AAH15882 BT009782 AAP88784 DC333017 L38934 AAB59574 L38938 U50315 AAC50778 XM_005257144 XP_005257201 XM_005257145 XP_005257202 XM_005257146 XP_005257203 XM_011524517 XP_011522819 XM_011524518 XP_011522820 XM_011524519 XP_011522821 NM_001991 NP_001982
Function	Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Enhancer of zeste homolog 1(Drosophila) Gene - orb92070 from Biorbyt Prices $366.00 Sizes 10 μg Species Human

Human-EZH1-cDNA-Clone - DC04214 from Abgent, a WuXi AppTec company Prices $1,008.45 Sizes 10 µg Species Human Accession BC015882

EZH1 - MBS1272386 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC015882

Human EZH1 ORF clone(NM_001991.3) - CDCL184125 from Creative Biomart Species Human Accession NM_001991.3

Human EZH1 ORF Clone(NM_001991.3) - CDCL162777 from Creative Biomart Species Human Accession NM_001991.3

Human SUV39H1 ORF clone(NM_001991.3) - CDCL186363 from Creative Biomart Species Human Accession NM_001991.3

Human SUV39H1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11498-NH from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11498-NF from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11498-CH from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11498-NM from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11498-CF from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11498-CM from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11498-M-F from Sino Biological Species Human

Human SUV39H1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11498-M-N from Sino Biological Species Human Accession NM_001991.3

Human SUV39H1 Gene ORF cDNA clone expression plasmid - HG11498-UT from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11498-NY from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11498-CY from Sino Biological Species Human

Human EZH1 ORF clone(NM_001991.3) - CDCL184125 from Creative biogene Species Human

Human EZH1 ORF Clone (BC015882) - CDCS410550 from Creative biogene Species Human Accession Q92800

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