EZH1

Gene Symbol EZH1
Entrez Gene 2145
Alt Symbol KMT6B
Species Human
Gene Type protein-coding
Description enhancer of zeste 1 polycomb repressive complex 2 subunit
Other Description ENX-2|enhancer of zeste homolog 1|histone-lysine N-methyltransferase EZH1
Swissprots Q92800 B4DSS2 B4DIZ7 A6NCH6 O43287 B4E3R7 B4DIJ1 Q53XP3 Q14459
Accessions EAW60870 EAW60871 Q92800 AB002386 BAA20842 AB004818 BAA25019 AK295626 BAG58503 AK295853 BAG58659 AK299887 BAG61734 AK304835 BAG65579 AK309121 AK310399 AK310556 AK311237 AL833159 BC015882 AAH15882 BT009782 AAP88784 DC333017 L38934 AAB59574 L38938 U50315 AAC50778 XM_005257144 XP_005257201 XM_005257145 XP_005257202 XM_005257146 XP_005257203 XM_011524517 XP_011522819 XM_011524518 XP_011522820 XM_011524519 XP_011522821 NM_001991 NP_001982
Function Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}.
Subcellular Location Nucleus {ECO:0000269|PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.

EZH1-Over-expression-Lysate - LY13659a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag EZH1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EZH1 gene.

EZH1 overexpression lysate - LY419594 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

EZH1 293 Cell Lysate - 409170 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Species Drosophila

EZH1 Overexpression Lysate (Native) - NBL1-10398 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: EZH1 Overexpression Lysate (Adult Normal) [NBL1-10398] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EZH1.

EZH1 Over-expression Lysate Product - GWB-1CA7A3 from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human EZH1 Knockdown Stable Cell Line - CSC-DC005161 from Creative biogene

Category Cell Line
Species Human
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