| Gene Symbol |
GMNN
|
| Entrez Gene |
51053
|
| Alt Symbol |
Gem
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
geminin, DNA replication inhibitor
|
| Other Description |
geminin
|
| Swissprots |
O75496 Q9H1Z1 B3KMM8
|
| Accessions |
CBL95030 CDH63540 EAW55465 EAW55466 O75496 AF067855 AAC39787 AK021685 BAG51040 AK222992 BAD96712 AK315743 AL558330 BC005185 AAH05185 BC005389 AAH05389 BF977182 BG777134 BM699599 CB131959 CB992796 HQ448314 ADQ32794 XM_005249159 XP_005249216 XM_011514651 XP_011512953 NM_001251989 NP_001238918 NM_001251990 NP_001238919 NM_001251991 NP_001238920 NM_015895 NP_056979
|
| Function |
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus.
|
![Western Blot: Geminin Overexpression Lysate (Adult Normal) [NBL1-11143] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Geminin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3412_Geminin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11143-img0002.jpg)