Gene Symbol | GMNN |
---|---|
Entrez Gene | 51053 |
Alt Symbol | Gem |
Species | Human |
Gene Type | protein-coding |
Description | geminin, DNA replication inhibitor |
Other Description | geminin |
Swissprots | O75496 Q9H1Z1 B3KMM8 |
Accessions | CBL95030 CDH63540 EAW55465 EAW55466 O75496 AF067855 AAC39787 AK021685 BAG51040 AK222992 BAD96712 AK315743 AL558330 BC005185 AAH05185 BC005389 AAH05389 BF977182 BG777134 BM699599 CB131959 CB992796 HQ448314 ADQ32794 XM_005249159 XP_005249216 XM_011514651 XP_011512953 NM_001251989 NP_001238918 NM_001251990 NP_001238919 NM_001251991 NP_001238920 NM_015895 NP_056979 |
Function | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. |
Subcellular Location | Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus. |