Gene Symbol | GMNN |
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Entrez Gene | 51053 |
Alt Symbol | Gem |
Species | Human |
Gene Type | protein-coding |
Description | geminin, DNA replication inhibitor |
Other Description | geminin |
Swissprots | O75496 Q9H1Z1 B3KMM8 |
Accessions | CBL95030 CDH63540 EAW55465 EAW55466 O75496 AF067855 AAC39787 AK021685 BAG51040 AK222992 BAD96712 AK315743 AL558330 BC005185 AAH05185 BC005389 AAH05389 BF977182 BG777134 BM699599 CB131959 CB992796 HQ448314 ADQ32794 XM_005249159 XP_005249216 XM_011514651 XP_011512953 NM_001251989 NP_001238918 NM_001251990 NP_001238919 NM_001251991 NP_001238920 NM_015895 NP_056979 |
Function | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. |
Subcellular Location | Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus. |
Geminin CRISPR/Cas9 KO Plasmid (h) - sc-416762 from Santa Cruz Biotechnology
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Geminin HDR Plasmid (h) - sc-416762-HDR from Santa Cruz Biotechnology
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Geminin Double Nickase Plasmid (h) - sc-416762-NIC from Santa Cruz Biotechnology
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Geminin Double Nickase Plasmid (h2) - sc-416762-NIC-2 from Santa Cruz Biotechnology
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Geminin CRISPR Activation Plasmid (h) - sc-416762-ACT from Santa Cruz Biotechnology
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Geminin CRISPR Activation Plasmid (h2) - sc-416762-ACT-2 from Santa Cruz Biotechnology
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Geminin Lentiviral Activation Particles (h) - sc-416762-LAC from Santa Cruz Biotechnology
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Geminin Lentiviral Activation Particles (h2) - sc-416762-LAC-2 from Santa Cruz Biotechnology
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Geminin siRNA (h) - sc-43800 from Santa Cruz Biotechnology
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Geminin shRNA Plasmid (h) - sc-43800-SH from Santa Cruz Biotechnology
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Geminin shRNA (h) Lentiviral Particles - sc-43800-V from Santa Cruz Biotechnology
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GEM RNAi - H00002669-R01 from Novus Biologicals
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GEM RNAi - H00002669-R02 from Novus Biologicals
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MISSION® esiRNA - EHU075141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9394 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9394 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02823 from Sigma-Aldrich
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GMNN siRNA (Human) - CRH9479 from Cohesion Biosciences
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Geminin RNAi - H00051053-R01 from Novus Biologicals
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GMNN - MBS8216161 from MyBioSource
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shRNA set against Human GMNN (NM_015895.4) - SHH304490 from Creative biogene
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Human GMNN siRNA - orb269981 from Biorbyt
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GMNN shRNA Plasmid (Human) - CHH9479 from Cohesion Biosciences
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GMNN miRNA 3'UTR clone - MiUTR3H-05341 from Creative biogene
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