| Gene Symbol |
RPS6KA1
|
| Entrez Gene |
6195
|
| Alt Symbol |
HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribosomal protein S6 kinase, 90kDa, polypeptide 1
|
| Other Description |
90 kDa ribosomal protein S6 kinase 1|MAP kinase-activated protein kinase 1a|MAPK-activated protein kinase 1a|MAPKAP kinase 1a|MAPKAPK-1a|RSK-1|S6K-alpha 1|S6K-alpha-1|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)|p90-RSK 1|p90RSK1|p90S6K|ribosomal S6 kinase 1|ribosomal protein S6 kinase alpha 1|ribosomal protein S6 kinase alpha-1
|
| Swissprots |
Q5SVM9 Q5SVM8 Q5SVM5 B2RDY8 Q96C05 A8K9K7 A6NGG4 Q15418 B7Z5J0 Q9BQK2 E9PRI4
|
| Accessions |
CAC36348 EAX07798 EAX07799 EAX07800 Q15418 AK092955 AK225672 AK292722 BAF85411 AK294818 BAH11893 AK299007 BAH12926 AK315730 BAG38085 BC014966 AAH14966 BC039069 BF982517 BM836865 DQ892242 ABM83168 DQ895443 ABM86369 L07597 AAC82497 XM_005245966 XP_005246023 XM_005245967 XP_005246024 XM_011541898 XP_011540200 XM_011548722 XP_011547024 XM_011548723 XP_011547025 XM_011548724 XP_011547026 NM_001006665 NP_001006666 NM_002953 NP_002944
|
| Function |
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin- derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promote
|
| Subcellular Location |
Nucleus. Cytoplasm.
|
| Top Pathways |
Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis
|