RPS6KA1

Gene Symbol	RPS6KA1
Entrez Gene	6195
Alt Symbol	HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 1
Other Description	90 kDa ribosomal protein S6 kinase 1|MAP kinase-activated protein kinase 1a|MAPK-activated protein kinase 1a|MAPKAP kinase 1a|MAPKAPK-1a|RSK-1|S6K-alpha 1|S6K-alpha-1|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)|p90-RSK 1|p90RSK1|p90S6K|ribosomal S6 kinase 1|ribosomal protein S6 kinase alpha 1|ribosomal protein S6 kinase alpha-1
Swissprots	Q5SVM9 Q5SVM8 Q5SVM5 B2RDY8 Q96C05 A8K9K7 A6NGG4 Q15418 B7Z5J0 Q9BQK2 E9PRI4
Accessions	CAC36348 EAX07798 EAX07799 EAX07800 Q15418 AK092955 AK225672 AK292722 BAF85411 AK294818 BAH11893 AK299007 BAH12926 AK315730 BAG38085 BC014966 AAH14966 BC039069 BF982517 BM836865 DQ892242 ABM83168 DQ895443 ABM86369 L07597 AAC82497 XM_005245966 XP_005246023 XM_005245967 XP_005246024 XM_011541898 XP_011540200 XM_011548722 XP_011547024 XM_011548723 XP_011547025 XM_011548724 XP_011547026 NM_001006665 NP_001006666 NM_002953 NP_002944
Function	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin- derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promote
Subcellular Location	Nucleus. Cytoplasm.
Top Pathways	Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RSK1 p90 full length protein - ab60880 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human RSK1 p90 full length protein - ab159427 from Abcam Category Protein Source Wheat germ Species Human

RPS6KA1 / RSK1 Antibody Blocking Peptide - LS-E5032 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPS6KA1 / RSK1 Antibody Blocking Peptide - LS-E30142 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RPS6KA1 / RSK1 Antibody Blocking Peptide - LS-E7387 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPS6KA1 / RSK1 Antibody Blocking Peptide - LS-E9384 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RSK1 Recombinant Protein - H00006195-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RSK1 Protein - P4205 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Source Insect Species Human

RSK1 Blocking Peptide - NBP1-76620PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant RSK1 Protein - NBP1-99478 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

RSK1 Peptide - P1595 from Novus Biologicals Category Peptide Species Human

RSK1 Peptide - P2927 from Novus Biologicals Category Peptide Species Human

Phospho-RPS6KA1S363-Antibody-Blocking-peptide - BP3461a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

RPS6KA1-Antibody-S732-Blocking-Peptide - BP7941e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Active RSK1, CF - 992-KS-010 from R&D Systems Category Protein

RSK1 protein - 30R-2836 from Fitzgerald Category Protein Prices $250.00 Sizes 5 µg Source Sf-9 insect cells Species Human

RSK1 (phospho-Ser380) Blocking Peptide - abx063223 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Rabbit

RPS6KA1 - H00006195-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPS6KA1 - H00006195-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPS6KA1 - P4205 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

RPS6KA1 Control Peptide - AP30741CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

RPS6K1 Peptide - 3511P from ProSci Category Peptide Species Human

RPS6KA1 fusion protein - ag9537 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RPS6KA1 fusion protein - Ag9655 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

p90RSK(Phospho-Thr348) Antibody Blocking Peptide - GWB-376B88 from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

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