RPS6KA1

Gene Symbol	RPS6KA1
Entrez Gene	6195
Alt Symbol	HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 1
Other Description	90 kDa ribosomal protein S6 kinase 1|MAP kinase-activated protein kinase 1a|MAPK-activated protein kinase 1a|MAPKAP kinase 1a|MAPKAPK-1a|RSK-1|S6K-alpha 1|S6K-alpha-1|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)|p90-RSK 1|p90RSK1|p90S6K|ribosomal S6 kinase 1|ribosomal protein S6 kinase alpha 1|ribosomal protein S6 kinase alpha-1
Swissprots	Q5SVM9 Q5SVM8 Q5SVM5 B2RDY8 Q96C05 A8K9K7 A6NGG4 Q15418 B7Z5J0 Q9BQK2 E9PRI4
Accessions	CAC36348 EAX07798 EAX07799 EAX07800 Q15418 AK092955 AK225672 AK292722 BAF85411 AK294818 BAH11893 AK299007 BAH12926 AK315730 BAG38085 BC014966 AAH14966 BC039069 BF982517 BM836865 DQ892242 ABM83168 DQ895443 ABM86369 L07597 AAC82497 XM_005245966 XP_005246023 XM_005245967 XP_005246024 XM_011541898 XP_011540200 XM_011548722 XP_011547024 XM_011548723 XP_011547025 XM_011548724 XP_011547026 NM_001006665 NP_001006666 NM_002953 NP_002944
Function	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin- derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promote
Subcellular Location	Nucleus. Cytoplasm.
Top Pathways	Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® RSK1 siRNA II - 6313 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® RSK1 siRNA I - 6309 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Rsk-1 CRISPR/Cas9 KO Plasmid (h) - sc-401073 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-1 HDR Plasmid (h) - sc-401073-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-1 Double Nickase Plasmid (h) - sc-401073-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-1 Double Nickase Plasmid (h2) - sc-401073-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-1 CRISPR Activation Plasmid (h) - sc-401073-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-1 CRISPR Activation Plasmid (h2) - sc-401073-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-1 Lentiviral Activation Particles (h) - sc-401073-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-1 Lentiviral Activation Particles (h2) - sc-401073-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rsk-1 siRNA (h) - sc-29475 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rsk-1 shRNA Plasmid (h) - sc-29475-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rsk-1 shRNA (h) Lentiviral Particles - sc-29475-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RSK1 RNAi - H00006195-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RSK1 RNAi - H00006195-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU030101 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK2005 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2004 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2006 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN18653 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18653 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13050 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr13050

RPS6KA1 siRNA (Human) - CRH4170 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RPS6KA1 - MBS8232054 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RPS6KA1 (NM_002953.3) - SHH399540 from Creative biogene Category siRNA Species Reactivities Human

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