RPS6KA1

Gene Symbol	RPS6KA1
Entrez Gene	6195
Alt Symbol	HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 1
Other Description	90 kDa ribosomal protein S6 kinase 1|MAP kinase-activated protein kinase 1a|MAPK-activated protein kinase 1a|MAPKAP kinase 1a|MAPKAPK-1a|RSK-1|S6K-alpha 1|S6K-alpha-1|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)|p90-RSK 1|p90RSK1|p90S6K|ribosomal S6 kinase 1|ribosomal protein S6 kinase alpha 1|ribosomal protein S6 kinase alpha-1
Swissprots	Q5SVM9 Q5SVM8 Q5SVM5 B2RDY8 Q96C05 A8K9K7 A6NGG4 Q15418 B7Z5J0 Q9BQK2 E9PRI4
Accessions	CAC36348 EAX07798 EAX07799 EAX07800 Q15418 AK092955 AK225672 AK292722 BAF85411 AK294818 BAH11893 AK299007 BAH12926 AK315730 BAG38085 BC014966 AAH14966 BC039069 BF982517 BM836865 DQ892242 ABM83168 DQ895443 ABM86369 L07597 AAC82497 XM_005245966 XP_005246023 XM_005245967 XP_005246024 XM_011541898 XP_011540200 XM_011548722 XP_011547024 XM_011548723 XP_011547025 XM_011548724 XP_011547026 NM_001006665 NP_001006666 NM_002953 NP_002944
Function	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin- derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promote
Subcellular Location	Nucleus. Cytoplasm.
Top Pathways	Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-RSK1 (Ser380) Sandwich ELISA Kit - 7965 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total RSK1 Sandwich ELISA Kit - 7966 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

RSK1 p90 (Total & pSer380) In-Cell ELISA (Fluorescent) - ab170196 from Abcam Prices $438.00 Sizes 1 x 96 tests Range 1563 cells/well - 100000 cells/well

RSK1 p90 ELISA Kit - ab173191 from Abcam Category ELISA Kit Sensitivity 1 ng/ml Range 3.9 ng/ml - 250 ng/ml

Mouse/Human Phospho-RPS6KA1 / RSK1 (Ser221/227) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1701 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat Phospho-RPS6KA1 / RSK1 (Thr359, Ser363) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1200 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat Phospho-RPS6KA1 / RSK1 (Ser380) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1201 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat Phospho-RPS6KA1 / RSK1 (Thr573) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1202 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human RPS6KA1 / RSK1 ELISA Kit (Cell-Based ELISA) - LS-F2293 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Mouse/Human/Rat RPS6KA1 / RSK1 ELISA Kit (Cell-Based ELISA) - LS-F2218 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Human RPS6KA1 / RSK1 ELISA Kit (Sandwich ELISA) - LS-F9489 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.117 ng/ml Range 0.313 - 20 ng/ml

Human Phospho-RSK1 (S380) DuoSet IC ELISA - DYC892B-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 125.00 - 8,000 pg/mL

Human Phospho-RSK1 (S380) DuoSet IC, 5 Plate - DYC892B-5 from R&D Systems Category ELISA Kit

Ribosomal Protein S6 Kinase Alpha 1 (RPS6Ka1), Human, ELISA Kit - SEM085Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.117ng/mL Range 0.312-20ng/mL

Human Phospho-RSK1 (S380) ELISA - PEL-RSK1-S380 from RayBiotech Category ELISA Kit Prices $481.00, $866.00, $1,924.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

p90 RSK Colorimetric Cell-Based ELISA Kit - CB5526 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

RSK1/2/3/4 Colorimetric Cell-Based ELISA Kit - CB5615 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

p90 RSK (Phospho-Thr359+Ser363) Colorimetric Cell-Based ELISA Kit - CBP1193 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

p90 RSK (Phospho-Ser380) Colorimetric Cell-Based ELISA Kit - CBP1194 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

p90 RSK (Phospho-Thr573) Colorimetric Cell-Based ELISA Kit - CBP1195 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

RSK1/2/3/4 (Phospho-Ser221/227/S218/232) Colorimetric Cell-Based ELISA Kit - CBP1772 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Ribosomal Protein S6 Kinase Alpha 1 (RPS6Ka1), ELISA Kit - MBS2000131 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.117ng/mL. Range 0.313-20ng/mL

ELISA Kit for Ribosomal Protein S6 Kinase Alpha 1 (RPS6Ka1) - SEM085Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Ribosomal Protein S6 Kinase Alpha 1 (RPS6Ka1) - SEM085Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Phospho-p90RSK Antibody Duo (Total, pT348) - ARG30176 from Arigo Biolaboratories Category Antibody Pair

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