RPS6KA1

Gene Symbol RPS6KA1
Entrez Gene 6195
Alt Symbol HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk
Species Human
Gene Type protein-coding
Description ribosomal protein S6 kinase, 90kDa, polypeptide 1
Other Description 90 kDa ribosomal protein S6 kinase 1|MAP kinase-activated protein kinase 1a|MAPK-activated protein kinase 1a|MAPKAP kinase 1a|MAPKAPK-1a|RSK-1|S6K-alpha 1|S6K-alpha-1|dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)|p90-RSK 1|p90RSK1|p90S6K|ribosomal S6 kinase 1|ribosomal protein S6 kinase alpha 1|ribosomal protein S6 kinase alpha-1
Swissprots Q5SVM9 Q5SVM8 Q5SVM5 B2RDY8 Q96C05 A8K9K7 A6NGG4 Q15418 B7Z5J0 Q9BQK2 E9PRI4
Accessions CAC36348 EAX07798 EAX07799 EAX07800 Q15418 AK092955 AK225672 AK292722 BAF85411 AK294818 BAH11893 AK299007 BAH12926 AK315730 BAG38085 BC014966 AAH14966 BC039069 BF982517 BM836865 DQ892242 ABM83168 DQ895443 ABM86369 L07597 AAC82497 XM_005245966 XP_005246023 XM_005245967 XP_005246024 XM_011541898 XP_011540200 XM_011548722 XP_011547024 XM_011548723 XP_011547025 XM_011548724 XP_011547026 NM_001006665 NP_001006666 NM_002953 NP_002944
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin- derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promote
Subcellular Location Nucleus. Cytoplasm.
Top Pathways Long-term potentiation, Progesterone-mediated oocyte maturation, MAPK signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis

Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 13588 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5D8
Flow cytometric analysis of Jurkat cells, untreated (blue) or treated with TPA #4174 (green), using Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor® 488 Conjugate).

Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate) - 13397 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5D8
Flow cytometric analysis of Jurkat cells, treated with UO126 #9903 (blue) or TPA #4174 (green), using Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (PE Conjugate).

Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 13575 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D5D8
Flow cytometric analysis of Jurkat cells, untreated (blue) or treated with TPA #4174 (green), using Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb (Alexa Fluor ® 647 Conjugate).

Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb - 12032 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5D8
Western blot analysis of extracts from various cell lines, starved overnight and untreated (-) or treated with either TPA #4174 (200 nM, 15 min; +), hEGF #8916 (100 ng/ml, 15 min; +), or hPDGF-BB #8912 (100 ng/ml, 15 min; +), using Phospho-p90RSK (Ser380) (D5D8) Rabbit mAb.

Phospho-p90RSK (Thr573) Antibody - 9346 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or TPA-treated (200 nM), using Phospho-p90RSK (Thr573) Antibody (upper) or RSK1/RSK2/RSK3 (32D7) Rabbit mAb #9355 (lower).

Phospho-p90RSK (Thr359) (D1E9) Rabbit mAb - 8753 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1E9
Western blot analysis of extracts from HeLa, COS-7, and A-431 cells, starved overnight and either untreated (-) or treated (+) with TPA #4174 (200 nM, 15 min) or Human Epidermal Growth Factor (hEGF) #8916 (100 ng/mL, 15 min), using Phospho-p90RSK (Thr359) (D1E9) Rabbit mAb.

Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb - 11989 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3H11
Western blot analysis of extracts from various cell lines, starved overnight and either untreated (-) or treated (+) with TPA #4174 (200 nM, 15 min), Human Epidermal Growth Factor (hEGF) #8916 (100 ng/mL, 15 min), or Human Platelet-Derived Growth Factor BB (hPDGF-BB) #8912 (100 ng/mL, 15 min) as indicated, using Phospho-p90RSK (Ser380) (D3H11) Rabbit mAb.

Phospho-p90RSK (Ser380) (9D9) Rabbit mAb - 9335 from Cell Signaling Technology

Prices $307.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 9D9
Western blot analysis of extracts from untreated or TPA-treated 293 and NIH/3T3 cells using Phospho-p90RSK (Ser380) (9D9) Rabbit mAb.

Phospho-RSK3 (Thr356/Ser360) Antibody - 9348 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and NIH/3T3 cells, untreated or TPA-treated, using Phospho-RSK3 (Thr356/Ser360) Antibody.

Phospho-p90RSK (Ser380) Antibody - 9341 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and C6 cells, untreated or TPA-treated (200 nM), using Phospho-p90RSK (Ser380) Antibody (upper) or control RSK1/RSK2/RSK3 Rabbit mAb #9355 (lower).

Phospho-p90RSK (Thr359/Ser363) Antibody - 9344 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and C6 cells, untreated or TPA-treated (200 nM), using Phospho-p90RSK (Thr359/Ser363) Antibody (upper) or control RSK1/RSK2/RSK3 Rabbit mAb #9355 (lower).

Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb - 3556 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D53A11
Western blot analysis of extracts from HeLa, COS and NIH/3T3 cells, treated with lambda-phosphatase or TPA/UV, using Phospho-RSK2 (Ser227) (D53A11) Rabbit mAb.

RSK1/RSK2/RSK3 Antibody - 9347 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from L929, JB6, HeLa, PC12 and COS cells, using RSK1/RSK2/RSK3 Antibody.

RSK1 (D6D5) Rabbit mAb - 8408 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6D5
Western blot analysis of extracts from various cell lines using RSK1 (D6D5) Rabbit mAb.

RSK1 Antibody - 9333 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of purified RSK1, RSK2, and RSK3 proteins using RSK1 Antibody (upper), RSK2 Antibody #9340 (middle) or RSK3 Antibody #9343 (lower).

RSK1/RSK2/RSK3 (32D7) Rabbit mAb - 9355 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 32D7
Western blot analysis of extracts from HeLa, L929 and AR42J cells, using RSK1/RSK2/RSK3 (32D7) Rabbit mAb.

Rsk-1 (C-21) - sc-231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of λ phosphatase-treated (A,C) and untreated (B,D) rat recombinant Rsk-1. Antibodies tested include Rsk-1 (C-21): sc-231 (A,B) and p-Rsk-1/2 (Thr 359/Ser 363)-R: sc-12898-R (C,D).

Rsk-1 (10B1D7) - sc-81162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rsk-1 (10B1D7): sc-81162. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing nuclear staining of glandular cells.

Rsk-1 (T12A6) - sc-81758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rsk-1 (T12A6): sc-81758. Western blot analysis of Rsk-1 expression in HeLa whole cell lysate.

Rsk-1 (A-10) - sc-393147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rsk-1 (A-10): sc-393147. Western blot analysis of Rsk-1 expression in HeLa (A), K-562 (B), Mv 1 Lu (C), A-431 (D) and MCF7 (E) whole cell lysates.

Rsk-1 (W-23) - sc-130870 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Rsk-1 (W-23): sc-130870. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma tissue showing cytoplasmic localization.

p-Rsk (C-5) - sc-377526 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Rsk phosphorylation in untreated (A,D), PMA treated (B,E) and PMA and lambda protein phosphatase (sc-200312A) treated (C,F) HeLa whole cell lysates. Antibodies tested include p-Rsk (C-5): sc-377526 (A,B,C) and Rsk-1 (C-21): sc-231 (D,E,F).

p-Rsk (Ser 380) - sc-11756 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Rsk phosphorylation in untreated (A,D), serum-starved, PMA-treated (B,E), serum-starved, PMA and lambda protein phosphatase (sc-200312A) treated (C,F) HeLa whole cell lysates. Antibodies tested include p-Rsk (Ser 380)-R: sc-11756-R (A,B,C) and Rsk-1 (C-21): sc-231 (D,E,F).

p-Rsk-1 (pS380.20A) - sc-136476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-Rsk-1 (pS380.20A): sc-136476. Western blot analysis of Rsk-1 phosphorylation in A-431 whole cell lysates either untreated (A) or treated (B) with EGF.

p-Rsk-1 (Ser 363) - sc-135634 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Rsk-1 (Ser 363): sc-135634. Western blot analysis of phosphorylated Rsk-1 expression in untreated (A) and Insulin-treated (B) HUVEC cell extracts.
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