PTPN11

Gene Symbol PTPN11
Entrez Gene 5781
Alt Symbol BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 11
Other Description PTP-2C|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C|tyrosine-protein phosphatase non-receptor type 11
Swissprots A8K1D9 Q96HD7 Q06124
Accessions EAW98011 EAW98012 Q06124 AK289854 BAF82543 AK312147 BAG35082 AU123593 BC007869 BC008692 AAH08692 BC025181 AAH25181 BC030949 AAH30949 BF515187 BT007106 AAP35770 BX537632 CN258646 D13540 BAA02740 EU779706 ACE60554 EU779707 ACE60555 EU779708 ACE60556 L03535 AAA36611 L07527 AAA17022 L08807 S39383 S78088 AAB21148 U79291 X70766 CAA50045 XM_006719526 XP_006719589 XM_006719527 XP_006719590 XM_011538613 XP_011536915 NM_002834 NP_002825 NM_080601 NP_542168
Function Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466}.
Subcellular Location Cytoplasm.
Tissue Specificity Widely expressed, with highest levels in heart, brain, and skeletal muscle. {ECO:0000269|PubMed:1280823, ECO:0000269|PubMed:7681589, ECO:0000269|PubMed:8216283}.
Top Pathways Proteoglycans in cancer, Jak-STAT signaling pathway, Herpes simplex infection, Neurotrophin signaling pathway, Renal cell carcinoma

Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb (PE Conjugate) - 13328 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D66F10
Flow cytometric analysis of NIH/3T3 cells, untreated (blue) or treated with Human Platelet-Derived Growth Factor BB (hPDGF-BB) #8912 (green), using Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb (PE Conjugate).

Phospho-SHP-2 (Tyr542) Antibody - 3751 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C6 and NIH/3T3 cells, starved for 18 hours and either untreated or PDGF-treated (50ng/ml, 20 minutes), using Phospho-SHP-2 (Tyr542) Antibody (upper) or control SHP-2 Antibody #3752 (lower).

Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb - 5431 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D66F10
Western blot analysis of extracts from C6 cells, serum-starved overnight and treated with PDGF (#9909, 50 ng/ml for 5 minutes), using Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb (upper) or total SHP-2 Antibody #3752 (lower).

Phospho-SHP-2 (Tyr580) Antibody - 3703 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell lysates from NIH/3T3 cells, serum-starved overnight and treated with PDGF (#9909) for 5 minutes, using Phospho-SHP-2 (Tyr580) Antibody (upper) or control SHP-2 Antibody #3752 (lower).

SHP-2 Antibody - 3752 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C6, NIH/3T3, 293 and HeLa cells, using SHP-2 Antibody.

SHP-2 (D50F2) Rabbit mAb - 3397 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D50F2
Western blot analysis of extracts from various cell lines using SHP-2 (D50F2) Rabbit mAb.

Phospho-SHP-2 (Tyr580) Antibody - 3754 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

SH-PTP2 (D-1) - sc-271106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SH-PTP2 (D-1): sc-271106. Western blot analysis of SH-PTP2 expression in non-transfected: sc-117752 (A) and mouse SH-PTP2 transfected: sc-123530 (B) 293T whole cell lysates.

SH-PTP2 (D-3) - sc-271053 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SH-PTP2 (D-3): sc-271053. Western blot analysis of SH-PTP2 expression in non-transfected 293T: sc-117752 (A), mouse SH-PTP2 transfected 293T: sc-123530 (B) and Jurkat (C) whole cell lysates.

SH-PTP2 (E-20) - sc-30688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SH-PTP2 (E-20): sc-30688. Western blot analysis of SH-PTP2 expression in Jurkat (A), A-431 (B), NIH/3T3 (C), U-937 (D), THP-1 (E) and U-87 MG (F) whole cell lysates.

SH-PTP2 (H-2) - sc-271550 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SH-PTP2 (H-2): sc-271550. Western blot analysis of SH-PTP2 expression in non-transfected: sc-117752 (A) and mouse SH-PTP2 transfected: sc-123530 (B) 293T whole cell lysates.

SH-PTP2 (G-15) - sc-30689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SH-PTP2 (G-15): sc-30689. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

SH-PTP2 (N-16) - sc-424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SH-PTP2 (N-16): sc-424. Western blot analysis of SH-PTP2 expression in Jurkat (A) and A-431 (B) whole cell lysates.

SH-PTP2 (N-17) - sc-30687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SH-PTP2 (N-17): sc-30687. Western blot analysis of SH-PTP2 expression in A-431 whole cell lysate

SH-PTP2 (C-18) - sc-280 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SH-PTP2 (C-18): sc-280. Western blot analysis of SH-PTP2 expression in human U-937 (A), A-431 (B), Jurkat (C) and mouse NIH/3T3 (D) whole cell lysates.

SH-PTP2 (B-1) - sc-7384 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SH-PTP2 (B-1): sc-7384. Western blot analysis of SH-PTP2 expression in Jurkat (A), NIH/3T3 (B), U-937 (C) and A-431 (D) whole cell lysates.

p-SH-PTP2 (Tyr 580) - sc-101799 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-SH-PTP2 (Tyr 580): sc-101799. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.

p-SH-PTP2 (Tyr 542) - sc-101798 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-SH-PTP2 (Tyr 542): sc-101798: Western blot analysis of phosphorylated SH-PTP2 expression in untreated (A) and insulin-treated (B) NIH/3T3 whole cell lysates.

Anti-SHP2 (phospho S576) antibody - ab17940 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SHP2 (phospho Y542) antibody - ab17939 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SHP2 (phospho Y542) antibody - ab51174 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SHP2 (phospho Y542) antibody (ab51174) at 1/500 dilution + extracts from A431 cells

Anti-SHP2 (phospho Y542) antibody - ab192210 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SHP2 (phospho Y542) antibody (ab192210) at 1/500 dilutionLane 1 : A431 whole cell lysate with antigen-specific peptideLane 2 : A431 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-SHP2 (phospho Y542) antibody [EP508(2)Y] - ab62322 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP508(2)Y
All lanes : Anti-SHP2 (phospho Y542) antibody [EP508(2)Y] (ab62322) at 1/50000 dilutionLane 1 : NIH/3T3 cell lysates; untreatedLane 2 : NIH/3T3 cell lysates; treated with PDGFLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP conjugated, at 1/2000 dilution

Anti-SHP2 (phospho Y580) antibody - ab17941 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SHP2 (phospho Y580) antibody - ab75818 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using ab75818, at 1/50 dilution, in the absence and presence of the immunising phosphopeptide
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