PTPN11

Gene Symbol	PTPN11
Entrez Gene	5781
Alt Symbol	BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 11
Other Description	PTP-2C|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C|tyrosine-protein phosphatase non-receptor type 11
Swissprots	A8K1D9 Q96HD7 Q06124
Accessions	EAW98011 EAW98012 Q06124 AK289854 BAF82543 AK312147 BAG35082 AU123593 BC007869 BC008692 AAH08692 BC025181 AAH25181 BC030949 AAH30949 BF515187 BT007106 AAP35770 BX537632 CN258646 D13540 BAA02740 EU779706 ACE60554 EU779707 ACE60555 EU779708 ACE60556 L03535 AAA36611 L07527 AAA17022 L08807 S39383 S78088 AAB21148 U79291 X70766 CAA50045 XM_006719526 XP_006719589 XM_006719527 XP_006719590 XM_011538613 XP_011536915 NM_002834 NP_002825 NM_080601 NP_542168
Function	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Widely expressed, with highest levels in heart, brain, and skeletal muscle. {ECO:0000269|PubMed:1280823, ECO:0000269|PubMed:7681589, ECO:0000269|PubMed:8216283}.
Top Pathways	Proteoglycans in cancer, Jak-STAT signaling pathway, Herpes simplex infection, Neurotrophin signaling pathway, Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® SHP-2 siRNA I - 7917 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® SHP-2 siRNA II - 7927 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SH-PTP2 CRISPR/Cas9 KO Plasmid (h) - sc-400260 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SH-PTP2 HDR Plasmid (h) - sc-400260-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SH-PTP2 Double Nickase Plasmid (h) - sc-400260-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SH-PTP2 Double Nickase Plasmid (h2) - sc-400260-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SH-PTP2 CRISPR Activation Plasmid (h) - sc-400260-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SH-PTP2 CRISPR Activation Plasmid (h2) - sc-400260-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SH-PTP2 Lentiviral Activation Particles (h) - sc-400260-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SH-PTP2 Lentiviral Activation Particles (h2) - sc-400260-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SH-PTP2 siRNA (h) - sc-36488 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SH-PTP2 shRNA Plasmid (h) - sc-36488-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SH-PTP2 shRNA (h) Lentiviral Particles - sc-36488-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SHP-2/PTPN11 RNAi - H00005781-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU105591 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0728 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0727 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0729 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN2123 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2123 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1294 from Sigma-Aldrich Category ZFN Kit Prices $6,000.00 Sizes 1 kt

PTPN11 siRNA (Human) - CRH3904 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PTPN11 (NM_002834.3) - SHH386432 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PTPN11(NM_002834.3) - SHR151440 from Creative biogene Category siRNA Species Reactivities Human

PTPN11 shRNA Plasmid (Human) - CHH3904 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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