PTPN11

Gene Symbol	PTPN11
Entrez Gene	5781
Alt Symbol	BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 11
Other Description	PTP-2C|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C|tyrosine-protein phosphatase non-receptor type 11
Swissprots	A8K1D9 Q96HD7 Q06124
Accessions	EAW98011 EAW98012 Q06124 AK289854 BAF82543 AK312147 BAG35082 AU123593 BC007869 BC008692 AAH08692 BC025181 AAH25181 BC030949 AAH30949 BF515187 BT007106 AAP35770 BX537632 CN258646 D13540 BAA02740 EU779706 ACE60554 EU779707 ACE60555 EU779708 ACE60556 L03535 AAA36611 L07527 AAA17022 L08807 S39383 S78088 AAB21148 U79291 X70766 CAA50045 XM_006719526 XP_006719589 XM_006719527 XP_006719590 XM_011538613 XP_011536915 NM_002834 NP_002825 NM_080601 NP_542168
Function	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Widely expressed, with highest levels in heart, brain, and skeletal muscle. {ECO:0000269|PubMed:1280823, ECO:0000269|PubMed:7681589, ECO:0000269|PubMed:8216283}.
Top Pathways	Proteoglycans in cancer, Jak-STAT signaling pathway, Herpes simplex infection, Neurotrophin signaling pathway, Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SHP2 protein fragment - ab42578 from Abcam Category Protein Prices $294.00 Sizes 20 µg Source E. coli Species Human

Avian Influenza A Nonstructural 1 peptide - ab51477 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human SHP2 peptide - ab14800 from Abcam Category Peptide

PTPN11 / SHP-2 / NS1 Antibody Blocking Peptide - LS-E30265 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PTPN11 / SHP-2 / NS1 Antibody Blocking Peptide - LS-E30266 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PTPN11 / SHP-2 / NS1 Antibody Blocking Peptide - LS-E20518 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPN11 / SHP-2 / NS1 Antibody Blocking Peptide - LS-E25227 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPN11 / SHP-2 / NS1 Antibody Blocking Peptide - LS-E8504 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SHP-2/PTPN11 Protein - H00005781-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SHP-2/PTPN11 Protein - H00005781-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SHP-2/PTPN11 Protein - H00005781-P03 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SHP-2/PTPN11 Peptide - NBP1-76404PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

SHP-2/PTPN11 Peptide - NBP1-76405PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

PTPN11-Antibody-C-term-Blocking-Peptide - BP6856b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SHP2-Antibody-Y546-Blocking-peptide - BP8471e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SHP2-Antibody-Y584-Blocking-Peptide - BP8471d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Active SHP-2, CF - 1894-SH-100 from R&D Systems Category Protein Source E. coli-derived, Ser2-Arg593, with an N-terminal 6-His tag

SHP2 peptide - orb73202 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

PTPN11 Immunizing peptide - orb17374 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Dengue NS1 protein (His tag) - 80-1348 from Fitzgerald Category Protein Prices $195.00 Sizes 100 µg Source E.coli

PTPN11 Blocking Peptide - 33R-3811 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TBCC protein (His tag) - 80R-2417 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

SHP2 Peptide - AC21-0051-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PTPN11 / PTP2C (Active Enzyme) - AR00173PU-N from Acris Antibodies Category Protein Prices $480.00 Sizes 20 µg Source E. coli Species Human

PTPN11 / PTP2C - H00005781-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Search more