PTPN11

Gene Symbol	PTPN11
Entrez Gene	5781
Alt Symbol	BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 11
Other Description	PTP-2C|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C|tyrosine-protein phosphatase non-receptor type 11
Swissprots	A8K1D9 Q96HD7 Q06124
Accessions	EAW98011 EAW98012 Q06124 AK289854 BAF82543 AK312147 BAG35082 AU123593 BC007869 BC008692 AAH08692 BC025181 AAH25181 BC030949 AAH30949 BF515187 BT007106 AAP35770 BX537632 CN258646 D13540 BAA02740 EU779706 ACE60554 EU779707 ACE60555 EU779708 ACE60556 L03535 AAA36611 L07527 AAA17022 L08807 S39383 S78088 AAB21148 U79291 X70766 CAA50045 XM_006719526 XP_006719589 XM_006719527 XP_006719590 XM_011538613 XP_011536915 NM_002834 NP_002825 NM_080601 NP_542168
Function	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Widely expressed, with highest levels in heart, brain, and skeletal muscle. {ECO:0000269|PubMed:1280823, ECO:0000269|PubMed:7681589, ECO:0000269|PubMed:8216283}.
Top Pathways	Proteoglycans in cancer, Jak-STAT signaling pathway, Herpes simplex infection, Neurotrophin signaling pathway, Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat PTPN11 / SHP-2 / NS1 ELISA Kit (Cell-Based ELISA) - LS-F2307 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-PTPN11 / SHP-2 / NS1 (Tyr580) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1055 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-PTPN11 / SHP-2 / NS1 (Tyr542) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1054 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Rat PTPN11 / SHP-2 / NS1 ELISA Kit (Sandwich ELISA) - LS-F7824 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.107 ng/ml Range 0.313-20 ng/ml

Human/Mouse/Rat Total SHP-2 DuoSet IC ELISA - DYC1894-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 156.00 - 10,000 pg/mL

Human/Mouse/Rat Phospho-SHP-2 (Y542) DuoSet IC ELISA - DYC3790-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 156.00 - 10,000 pg/mL

Human/Mouse/Rat Phospho-SHP-2 (Y542) DuoSet IC, 5 Plate - DYC3790-5 from R&D Systems Category ELISA Kit

Human/Mouse/Rat Active SHP-2 DuoSet IC, 1 Plate - DYC2809 from R&D Systems Prices $455.00 Sizes 1 kit (for 1 Plate)

SHP-2, Human, ELISA Kit - E01S0105 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11), Human, ELISA Kit - E01T0638 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Human/Mouse/Rat Phospho-SHP2 (Y542) ELISA - PEL-SHP2-Y542 from RayBiotech Category ELISA Kit Prices $481.00, $866.00, $1,924.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

PTPN11, ELISA Kit - MBS2516127 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

SHP-2 Colorimetric Cell-Based ELISA Kit - CB5631 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SHP-2 (Phospho-Tyr542) Colorimetric Cell-Based ELISA Kit - CBP1026 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SHP-2 (Phospho-Tyr580) Colorimetric Cell-Based ELISA Kit - CBP1027 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11), ELISA Kit - MBS9308107 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Shp-2, ELISA Kit - MBS064520 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Shp-2, ELISA Kit - MBS086316 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Shp-2, ELISA Kit - MBS055136 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Shp-2, ELISA Kit - MBS009388 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Shp-2, ELISA Kit - MBS045509 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Shp-2, ELISA Kit - MBS043488 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Shp-2, ELISA Kit - MBS102642 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine protein phosphatase non receptor type 11 (PTPN11), ELISA Kit - MBS7206802 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) - SED584Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.107ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

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