| Gene Symbol |
PTPN11
|
| Entrez Gene |
5781
|
| Alt Symbol |
BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, non-receptor type 11
|
| Other Description |
PTP-2C|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C|tyrosine-protein phosphatase non-receptor type 11
|
| Swissprots |
A8K1D9 Q96HD7 Q06124
|
| Accessions |
EAW98011 EAW98012 Q06124 AK289854 BAF82543 AK312147 BAG35082 AU123593 BC007869 BC008692 AAH08692 BC025181 AAH25181 BC030949 AAH30949 BF515187 BT007106 AAP35770 BX537632 CN258646 D13540 BAA02740 EU779706 ACE60554 EU779707 ACE60555 EU779708 ACE60556 L03535 AAA36611 L07527 AAA17022 L08807 S39383 S78088 AAB21148 U79291 X70766 CAA50045 XM_006719526 XP_006719589 XM_006719527 XP_006719590 XM_011538613 XP_011536915 NM_002834 NP_002825 NM_080601 NP_542168
|
| Function |
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Widely expressed, with highest levels in heart, brain, and skeletal muscle. {ECO:0000269|PubMed:1280823, ECO:0000269|PubMed:7681589, ECO:0000269|PubMed:8216283}.
|
| Top Pathways |
Proteoglycans in cancer, Jak-STAT signaling pathway, Herpes simplex infection, Neurotrophin signaling pathway, Renal cell carcinoma
|
