OSBP

Gene Symbol OSBP
Entrez Gene 5007
Alt Symbol OSBP1
Species Human
Gene Type protein-coding
Description oxysterol binding protein
Other Description oxysterol-binding protein 1
Swissprots P22059 Q6P524
Accessions AAG28373 EAW73849 P22059 AF185696 AAG17011 AK299071 BAG61137 AK310538 BC011581 AAH11581 BC017975 BC051350 BC063121 AAH63121 M86917 AAA59973 NM_002556 NP_002547
Function Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:18450749}.
Subcellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11278871}.

OSBP (C-13) - sc-49466 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OSBP (C-13): sc-49466. Western blot analysis of OSBP expression in HUV-EC-C (A) and JAR (B) whole cell lysates.

OSBP (E-20) - sc-49467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OSBP (E-20): sc-49467. Western blot analysis of OSBP expression in HUV-EC-C (A) and JAR (B) whole cell lysates.

OSBP (H-60) - sc-134747 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-OSBP1 antibody - ab126182 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-OSBP1 antibody (ab126182) at 1/1000 dilutionLane 1 : Jurkat whole cell lysateLane 2 : Raji whole cell lysateLane 3 : K562 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-OSBP1 antibody - ab188019 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human kidney tissue, labeling OSBP1 using ab188019 at a 1/50 dilution.

Anti-OSBP1 antibody - ab5915 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-OSBP1 antibody (ab5915) at 2 µg/ml + Lysate prepared from human Liver at 35 µgdeveloped using the ECL technique

Anti-OSBP1 antibody [1A4] - ab119187 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A4
ab119187 at 1/150 dilution staining OSPB1 in Paraffin-embedded Human breast adenocarcinoma tissue by Immunohistochemistry.

Anti-OSBP Antibody (clone 1F2) - LS-C337411 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F2
IHC of paraffin-embedded Human endometrium tissue using anti-OSBP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-OSBP Antibody (C-Terminus) - LS-C155383 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: Jurkat B: Raji C: K562 7.5% SDS PAGE OSBP antibody diluted at 1:1000

Anti-OSBP Antibody (aa290-304) - LS-C313083 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of OSBP antibody. Lane 1: Rat Kidney Tissue Lysate. Lane 2: Rat Spleen Tissue Lysate. Lane 3: Rat Lung Tissue Lysate. Lane 4: HELA Cell Lysate. Lane 5: A549 Cell Lysate.

Anti-OSBP Antibody (aa794-807) - LS-C55214 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
OSBP antibody (2 ug/ml) staining of Human Liver lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OSBP Antibody (aa700-749) - LS-C135741 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OSBP antibody LS-C135741 Western blot of Fetal Muscle lysate.

Anti-OSBP Antibody (aa395-410) - LS-C55213 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OSBP Antibody (clone 5A3) - LS-C197827 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5A3
OSBP monoclonal antibody (M01), clone 5A3. Western Blot analysis of OSBP expression in Jurkat.

Anti-OSBP Antibody (clone 1A4) - LS-C337423 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A4
IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-OSBP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

OSBP1 Antibody (1F2) - NBP2-00935 from Novus Biologicals

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F2
Western Blot: OSBP1 Antibody (1F2) [NBP2-00935] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY OSBP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-OSBP1.

OSBP1 Antibody - NB100-1500 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

OSBP1 Antibody - NBP2-15057 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OSBP1 Antibody [NBP2-15057] - Sample (30 ug of whole cell lysate) A: Raji 7.5% SDS PAGE; antibody diluted at 1:1000.

OSBP1 Antibody - NB100-1329 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: OSBP1 Antibody [NB100-1329] - (2ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

OSBP1 Antibody - NBP2-15056 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OSBP1 Antibody [NBP2-15056] - Sample (30 ug of whole cell lysate) A: Jurkat B: Raji C: K562 7. 5% SDS PAGE; antibody diluted at 1:1000.

OSBP1 Antibody (5A3) - H00005007-M01-100ug from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5A3

Anti-OSBP antibody produced in rabbit - HPA039227 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OSBP: <B>Cat. No. HPA039227</B>: Immunohistochemical staining of human breast shows strong cytoplasmic positivity in glandular cells.

Anti-OSBP antibody produced in rabbit - HPA043625 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OSBP: <B>Cat. No. HPA043625</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in renal tubules.

Anti-OSBP antibody produced in goat - SAB2500726 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-OSBP: <B>Cat. No. SAB2500726</B>: (0.1 μg/mL) staining of Human Placenta lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OSBP (661-675) antibody produced in rabbit - SAB1100707 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-OSBP (661-675) : <B>Cat. No. SAB1100707</B>: Immunofluorescence of HUVEC cells using OSBP (661-675) , Cat. No. SAB1100707 (red) at a 1:400 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com
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