| Gene Symbol |
OSBP
|
| Entrez Gene |
5007
|
| Alt Symbol |
OSBP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
oxysterol binding protein
|
| Other Description |
oxysterol-binding protein 1
|
| Swissprots |
P22059 Q6P524
|
| Accessions |
AAG28373 EAW73849 P22059 AF185696 AAG17011 AK299071 BAG61137 AK310538 BC011581 AAH11581 BC017975 BC051350 BC063121 AAH63121 M86917 AAA59973 NM_002556 NP_002547
|
| Function |
Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:18450749}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11278871}.
|