OSBP

Gene Symbol OSBP
Entrez Gene 5007
Alt Symbol OSBP1
Species Human
Gene Type protein-coding
Description oxysterol binding protein
Other Description oxysterol-binding protein 1
Swissprots P22059 Q6P524
Accessions AAG28373 EAW73849 P22059 AF185696 AAG17011 AK299071 BAG61137 AK310538 BC011581 AAH11581 BC017975 BC051350 BC063121 AAH63121 M86917 AAA59973 NM_002556 NP_002547
Function Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:18450749}.
Subcellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11278871}.

OSBP CRISPR/Cas9 KO Plasmid (h) - sc-409659 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OSBP HDR Plasmid (h) - sc-409659-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OSBP Double Nickase Plasmid (h) - sc-409659-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OSBP Double Nickase Plasmid (h2) - sc-409659-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OSBP CRISPR Activation Plasmid (h) - sc-409659-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OSBP CRISPR Activation Plasmid (h2) - sc-409659-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OSBP Lentiviral Activation Particles (h) - sc-409659-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OSBP Lentiviral Activation Particles (h2) - sc-409659-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OSBP siRNA (h) - sc-61264 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OSBP shRNA Plasmid (h) - sc-61264-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OSBP shRNA (h) Lentiviral Particles - sc-61264-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU119311 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16155 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11087 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11087

OSBP siRNA (Human) - CRH3324 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human OSBP (NM_002556.2) - SHH368576 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human OSBP(NM_002556.2) - SHR081366 from Creative biogene

Category siRNA
Species Reactivities Human

Human OSBP siRNA - orb263826 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

OSBP shRNA Plasmid (Human) - CHH3324 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

OSBP miRNA 3'UTR clone - MiUTR1H-07393 from Creative biogene

Species Reactivities Human
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