Gene Symbol | OSBP |
---|---|
Entrez Gene | 5007 |
Alt Symbol | OSBP1 |
Species | Human |
Gene Type | protein-coding |
Description | oxysterol binding protein |
Other Description | oxysterol-binding protein 1 |
Swissprots | P22059 Q6P524 |
Accessions | AAG28373 EAW73849 P22059 AF185696 AAG17011 AK299071 BAG61137 AK310538 BC011581 AAH11581 BC017975 BC051350 BC063121 AAH63121 M86917 AAA59973 NM_002556 NP_002547 |
Function | Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. {ECO:0000269|PubMed:15746430, ECO:0000269|PubMed:18450749}. |
Subcellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11278871}. |
Human OSBP1 peptide - ab23121 from Abcam
|
||||||||||
Human OSBP1 protein fragment - ab152583 from Abcam
|
||||||||||
OSBP1 peptide (395-410) - ab45716 from Abcam
|
||||||||||
OSBP Antibody Blocking Peptide - LS-E25627 from LifeSpan Bioscience
|
||||||||||
OSBP Antibody Blocking Peptide - LS-E22042 from LifeSpan Bioscience
|
||||||||||
OSBP Antibody Blocking Peptide - LS-E25856 from LifeSpan Bioscience
|
||||||||||
Recombinant Human OSBP1 Protein - H00005007-Q01 from Novus Biologicals
|
||||||||||
OSBP-Antibody-Center-Blocking-peptide - BP11453c from Abgent, a WuXi AppTec company
|
||||||||||
OSBP blocking peptide - GTX89571-PEP from GeneTex
|
||||||||||
OSBP1 (C Terminus) blocking peptide - GTX25915-PEP from GeneTex
|
||||||||||
OSBP Immunizing peptide - orb17942 from Biorbyt
|
||||||||||
OSBP1 Peptide - AC21-0458-P from Abcore
|
||||||||||
OSBP1 Peptide - AC21-0686-P from Abcore
|
||||||||||
OSBP - H00005007-Q01-10 from Acris Antibodies
|
||||||||||
OSBP - H00005007-Q01-25 from Acris Antibodies
|
||||||||||
OSBP Peptide - 46-113P from ProSci
|
||||||||||
OSBP1 Peptide - 46-114P from ProSci
|
||||||||||
OSBP fusion protein - ag1578 from Proteintech Group
|
||||||||||
Recombinant Human Oxysterol-binding protein 1(OSBP) ,partial - CSB-YP017243HU CSB-EP017243HU CSB-BP017243HU CSB-MP017243HU from Cusabio
|
||||||||||
OSBP - TP304250 from Acris Antibodies
|
||||||||||
OSBP, Peptide - MBS426165 from MyBioSource
|
||||||||||
OSBP1, Peptide - MBS428057 from MyBioSource
|
||||||||||
Recombinant Oxysterol Binding Protein (OSBP) - RPC694Hu01 from Uscn Life Science Inc.
|
||||||||||
OSBP1 Recombinant Protein Antigen - NBP2-47343PEP from Novus Biologicals
|
||||||||||
OSBP1 Recombinant Protein Antigen - NBP2-47342PEP from Novus Biologicals
|