POMK

Gene Symbol POMK
Entrez Gene 84197
Alt Symbol MDDGA12, MDDGC12, SGK196
Species Human
Gene Type protein-coding
Description protein-O-mannose kinase
Other Description Sugen kinase 196|probable inactive protein kinase-like protein SgK196|protein O-mannose kinase|protein kinase-like protein SgK196
Swissprots Q9H5K3
Accessions EAW63187 Q9H5K3 BC101548 AAI01549 BC113703 AAI13704 BQ365114 DA074115 DA330953 DA383787 DA818523 EH337134 XM_011544668 XP_011542970 XM_011544669 XP_011542971 NM_001277971 NP_001264900 NM_032237 NP_115613
Function Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N- acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. {ECO:0000269|PubMed:23519211, ECO:0000269|PubMed:23929950}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues. {ECO:0000269|PubMed:24925318}.

SGK196 (Human) IP-WB Antibody Pair - H00084197-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Human POMK ELISA Kit - E097705 from Biobool

Category ELISA Kit
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