POMK

Gene Symbol POMK
Entrez Gene 84197
Alt Symbol MDDGA12, MDDGC12, SGK196
Species Human
Gene Type protein-coding
Description protein-O-mannose kinase
Other Description Sugen kinase 196|probable inactive protein kinase-like protein SgK196|protein O-mannose kinase|protein kinase-like protein SgK196
Swissprots Q9H5K3
Accessions EAW63187 Q9H5K3 BC101548 AAI01549 BC113703 AAI13704 BQ365114 DA074115 DA330953 DA383787 DA818523 EH337134 XM_011544668 XP_011542970 XM_011544669 XP_011542971 NM_001277971 NP_001264900 NM_032237 NP_115613
Function Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N- acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. {ECO:0000269|PubMed:23519211, ECO:0000269|PubMed:23929950}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues. {ECO:0000269|PubMed:24925318}.

SGK196-Over-expression-Lysate - LY16634a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SGK196 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SGK196 gene‘

FLJ23356-Over-expression-Lysate - LY10265a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag FLJ23356 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FLJ23356 gene (Lane 2, Cat. #LY10265a).

FLJ23356 293T Cell Transient Overexpression Lysate(Denatured) - H00084197-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

POMK overexpression lysate - LY410261 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SGK196 293 Cell Lysate - 405284 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

FLJ23356 Overexpression Lysate (Native) - NBP2-06056 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: FLJ23356 Overexpression Lysate (Adult Normal) [NBP2-06056] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FLJ23356.

FLJ23356 (h): 293T Lysate - sc-372757 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

SGK196 Over-expression Lysate Product - GWB-9B9D08 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

FLJ23356 Overexpression Lysate (Denatured) - H00084197-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human SGK196 Knockdown Stable Cell Line - CSC-DC014135 from Creative biogene

Category Cell Line
Species Human
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