Gene Symbol | POMK |
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Entrez Gene | 84197 |
Alt Symbol | MDDGA12, MDDGC12, SGK196 |
Species | Human |
Gene Type | protein-coding |
Description | protein-O-mannose kinase |
Other Description | Sugen kinase 196|probable inactive protein kinase-like protein SgK196|protein O-mannose kinase|protein kinase-like protein SgK196 |
Swissprots | Q9H5K3 |
Accessions | EAW63187 Q9H5K3 BC101548 AAI01549 BC113703 AAI13704 BQ365114 DA074115 DA330953 DA383787 DA818523 EH337134 XM_011544668 XP_011542970 XM_011544669 XP_011542971 NM_001277971 NP_001264900 NM_032237 NP_115613 |
Function | Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N- acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. {ECO:0000269|PubMed:23519211, ECO:0000269|PubMed:23929950}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues. {ECO:0000269|PubMed:24925318}. |
FLJ23356 (G-18) - sc-87126 from Santa Cruz Biotechnology
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FLJ23356 (P-18) - sc-87127 from Santa Cruz Biotechnology
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FLJ23356 (S-23) - sc-100433 from Santa Cruz Biotechnology
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Anti-SGK196 antibody - ab57908 from Abcam
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Anti-SGK196 antibody - ab81537 from Abcam
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Anti-SGK196 antibody - ab172711 from Abcam
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Anti-POMK / SGK196 Antibody (aa244-273, APC) - LS-C269209 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa244-273, AP) - LS-C269208 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa244-273, Biotin) - LS-C269211 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa244-273, FITC) - LS-C269212 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa244-273, Azide-free, HRP) - LS-C269213 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa251-351) - LS-C308016 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa244-273, PE) - LS-C269214 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody - LS-C310371 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody - LS-C308026 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody - LS-C310374 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa244-273) - LS-C330120 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa74-123) - LS-C81507 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa245-273) - LS-C164573 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa141-350, clone 4F6) - LS-C339263 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa141-350, clone 2E6) - LS-C339289 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa141-350, clone 4G2) - LS-C339262 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa141-350, clone 2B6) - LS-C339250 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa141-350, clone 1B1) - LS-C339249 from LifeSpan Bioscience
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Anti-POMK / SGK196 Antibody (aa141-350, clone 2B10) - LS-C339248 from LifeSpan Bioscience
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