| Gene Symbol |
BUB3
|
| Entrez Gene |
9184
|
| Alt Symbol |
BUB3L, hBUB3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BUB3 mitotic checkpoint protein
|
| Other Description |
BUB3 budding uninhibited by benzimidazoles 3 homolog|budding uninhibited by benomyl|budding uninhibited by benzimidazoles 3 homolog|mitotic checkpoint component|mitotic checkpoint protein BUB3
|
| Swissprots |
O43684 O43685 B2R6E7 A6NJ42 D3DRE9
|
| Accessions |
AAL17976 EAW49284 EAW49285 EAW49286 EAW49287 O43684 AF047472 AAC28438 AF047473 AAC28439 AF053304 AAC06258 AF081496 AAC36307 AK226060 AK293255 BAG56787 AK307958 AK312546 BAG35444 BC005138 AAH05138 BC022438 AAH22438 BM989334 BP328027 BU932619 BX647392 DQ891852 ABM82778 DQ895042 ABM85968 NM_001007793 NP_001007794 NM_004725 NP_004716
|
| Function |
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.
|
| Top Pathways |
Cell cycle, HTLV-I infection
|