TP53RK

Gene Symbol TP53RK
Entrez Gene 112858
Alt Symbol BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2
Species Human
Gene Type protein-coding
Description TP53 regulating kinase
Other Description EKC/KEOPS complex subunit TP53RK|TP53-regulating kinase|atypical serine/threonine protein kinase TP53RK|p53-related protein kinase
Swissprots Q6NZ60 Q3T977 B3KU44 Q9NQE6 Q96FM7 Q5JZ01 Q96S44
Accessions EAW75727 Q96S44 AB017505 BAB61875 AB065434 BAB62041 AK096502 BAG53306 AK315182 BAG37623 BC009727 AAH09727 BC010637 AAH10637 BC019621 BC035461 BC066309 AAH66309 BM702732 NM_033550 NP_291028
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. {ECO:0000250, ECO:0000269|PubMed:11546806}.
Subcellular Location Nucleus {ECO:0000269|PubMed:22912744}.
Tissue Specificity Highly expressed in testis. Weakly expressed in heart kidney and spleen.

PRPK (G-10) - sc-398705 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRPK (G-10): sc-398705. Western blot analysis of PRPK expression in K-562 (A), Jurkat (B) and Hep G2 (C) whole cell lysates.

PRPK (C-14) - sc-85846 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PRPK (C-14): sc-85846. Western blot analysis of PRPK expression in Jurkat (A), K-562 (B), COLO 205 (C) and HL-60 (D) whole cell lysates.

PRPK (V-16) - sc-85848 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PRPK (F-9) - sc-100350 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PRPK (F-9): sc-100350. Western blot analysis of PRPK expression in Jurkat whole cell lysate.

Anti-PRPK antibody - ab37606 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PRPK antibody (ab37606) at 1/100 dilution + Mouse thymus tissue lysate

Anti-PRPK antibody - ab57700 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
PRPK antibody (ab57700) used in immunohistochemistry at 2ug/ml on formalin fixed and paraffin embedded human lymphoma tissue.

Anti-PRPK antibody - ab57702 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PRPK / TP53RK Antibody (aa221-250, APC) - LS-C242020 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa221-250, Biotin) - LS-C242021 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa221-250, FITC) - LS-C242023 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa221-250, PE) - LS-C242024 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa100-128, AP) - LS-C242025 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa100-128, APC) - LS-C242026 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa100-128, Biotin) - LS-C242027 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa100-128, FITC) - LS-C242028 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa100-128, PE) - LS-C242032 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (Internal, AP) - LS-C245503 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (clone 2E8) - LS-C105198 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E8
Detection limit for recombinant GST tagged TP53RK is approximately 1 ng/ml as a capture antibody.

Anti-PRPK / TP53RK Antibody (Internal, APC) - LS-C245504 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (Internal, Biotin) - LS-C245505 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (Internal, FITC) - LS-C245506 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (Internal, PE) - LS-C245510 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa221-250, Azide-free, HRP) - LS-C247111 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (aa100-128, Azide-free, HRP) - LS-C247112 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRPK / TP53RK Antibody (N-Terminus) - LS-C135278 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TP53RK antibody LS-C135278 Western blot of HT1080 cell lysate.
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