TP53RK

Gene Symbol TP53RK
Entrez Gene 112858
Alt Symbol BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2
Species Human
Gene Type protein-coding
Description TP53 regulating kinase
Other Description EKC/KEOPS complex subunit TP53RK|TP53-regulating kinase|atypical serine/threonine protein kinase TP53RK|p53-related protein kinase
Swissprots Q6NZ60 Q3T977 B3KU44 Q9NQE6 Q96FM7 Q5JZ01 Q96S44
Accessions EAW75727 Q96S44 AB017505 BAB61875 AB065434 BAB62041 AK096502 BAG53306 AK315182 BAG37623 BC009727 AAH09727 BC010637 AAH10637 BC019621 BC035461 BC066309 AAH66309 BM702732 NM_033550 NP_291028
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. {ECO:0000250, ECO:0000269|PubMed:11546806}.
Subcellular Location Nucleus {ECO:0000269|PubMed:22912744}.
Tissue Specificity Highly expressed in testis. Weakly expressed in heart kidney and spleen.

PRPK CRISPR/Cas9 KO Plasmid (h) - sc-405589 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRPK HDR Plasmid (h) - sc-405589-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRPK Double Nickase Plasmid (h) - sc-405589-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRPK Double Nickase Plasmid (h2) - sc-405589-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRPK CRISPR Activation Plasmid (h) - sc-405589-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRPK CRISPR Activation Plasmid (h2) - sc-405589-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRPK Lentiviral Activation Particles (h) - sc-405589-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRPK Lentiviral Activation Particles (h2) - sc-405589-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRPK siRNA (h) - sc-76259 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRPK shRNA Plasmid (h) - sc-76259-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRPK shRNA (h) Lentiviral Particles - sc-76259-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRPK RNAi - H00112858-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU005331 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK2315 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2317 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2316 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN21850 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21850 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12926 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12926

TP53RK siRNA (Human) - CRJ4296 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TP53RK - MBS8215355 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TP53RK (NM_033550.3) - SHH433120 from Creative biogene

Category siRNA
Species Reactivities Human

TP53RK shRNA Plasmid (Human) - CHJ4296 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TP53RK miRNA 3'UTR clone - MiUTR1H-10659 from Creative biogene

Species Reactivities Human
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