| Gene Symbol |
TP53RK
|
| Entrez Gene |
112858
|
| Alt Symbol |
BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TP53 regulating kinase
|
| Other Description |
EKC/KEOPS complex subunit TP53RK|TP53-regulating kinase|atypical serine/threonine protein kinase TP53RK|p53-related protein kinase
|
| Swissprots |
Q6NZ60 Q3T977 B3KU44 Q9NQE6 Q96FM7 Q5JZ01 Q96S44
|
| Accessions |
EAW75727 Q96S44 AB017505 BAB61875 AB065434 BAB62041 AK096502 BAG53306 AK315182 BAG37623 BC009727 AAH09727 BC010637 AAH10637 BC019621 BC035461 BC066309 AAH66309 BM702732 NM_033550 NP_291028
|
| Function |
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. {ECO:0000250, ECO:0000269|PubMed:11546806}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:22912744}.
|
| Tissue Specificity |
Highly expressed in testis. Weakly expressed in heart kidney and spleen.
|
![Western Blot: PRPK Overexpression Lysate (Adult Normal) [NBL1-17207] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PRPK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2239_PRPK%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17207-img0002.jpg)