TP53RK

Gene Symbol	TP53RK
Entrez Gene	112858
Alt Symbol	BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2
Species	Human
Gene Type	protein-coding
Description	TP53 regulating kinase
Other Description	EKC/KEOPS complex subunit TP53RK|TP53-regulating kinase|atypical serine/threonine protein kinase TP53RK|p53-related protein kinase
Swissprots	Q6NZ60 Q3T977 B3KU44 Q9NQE6 Q96FM7 Q5JZ01 Q96S44
Accessions	EAW75727 Q96S44 AB017505 BAB61875 AB065434 BAB62041 AK096502 BAG53306 AK315182 BAG37623 BC009727 AAH09727 BC010637 AAH10637 BC019621 BC035461 BC066309 AAH66309 BM702732 NM_033550 NP_291028
Function	Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. {ECO:0000250, ECO:0000269|PubMed:11546806}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22912744}.
Tissue Specificity	Highly expressed in testis. Weakly expressed in heart kidney and spleen.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PRPK full length protein - ab169728 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PRPK full length protein - ab164985 from Abcam Category Protein Source Wheat germ Species Human

Human PRPK protein fragment - ab164986 from Abcam Category Protein Source Wheat germ Species Human

PRPK / TP53RK Antibody Blocking Peptide - LS-E3153 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRPK / TP53RK Antibody Blocking Peptide - LS-E4649 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRPK / TP53RK Antibody Blocking Peptide - LS-E18861 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRPK / TP53RK Antibody Blocking Peptide - LS-E9493 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PRPK Protein - H00112858-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PRPK Protein - H00112858-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PRPK Peptide - P3103 from Novus Biologicals Category Peptide Species Human

TP53RK-Antibody-C-term-Blocking-Peptide - BP17010b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRPK-Antibody-Center-Blocking-Peptide - BP8097c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TP53RK Blocking Peptide - 33R-5585 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TP53RK - H00112858-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TP53RK - H00112858-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TP53RK - H00112858-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TP53RK - H00112858-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TP53RK fusion protein - ag13600 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human TP53RK, GST-tagged - TP53RK-197H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

TP53RK protein-GST fusion - 009-001-U16 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

TP53RK protein-GST fusion - 009-001-U16S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human TP53-regulating kinase(TP53RK) - CSB-YP822302HU CSB-EP822302HU CSB-BP822302HU CSB-MP822302HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TP53RK (full length, N-term HIS tag) - TP760196 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

PRPK Recombinant Protein Antigen - NBP1-89919PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TP53RK fusion protein - Ag25326 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

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