| Gene Symbol |
IGF2R
|
| Entrez Gene |
3482
|
| Alt Symbol |
CD222, CIMPR, M6P-R, MPR1, MPRI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
insulin-like growth factor 2 receptor
|
| Other Description |
300 kDa mannose 6-phosphate receptor|CI Man-6-P receptor|CI-MPR|IGF-II receptor|M6P/IGF2 receptor|M6P/IGF2R|M6PR|MPR 300|cation-independent mannose-6 phosphate receptor|cation-independent mannose-6-phosphate receptor|insulin-like growth factor II receptor
|
| Swissprots |
P11717 Q96PT5 Q7Z7G9
|
| Accessions |
AAF16870 AAK56918 AAL04402 AAP37954 CAA58672 CAA58673 CAA58674 CAA58675 CAA62977 EAW47607 P11717 AB209668 BAD92905 AK300848 BAG62499 BC172256 AAI72256 J03528 AAA59866 S80783 AAB35664 S80785 AAB35665 S80797 AAD14337 Y00285 CAA68395 XR_942419 NM_000876 NP_000867
|
| Function |
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. {ECO:0000269|PubMed:10900005}.
|
| Subcellular Location |
Lysosome membrane {ECO:0000269|PubMed:10900005}; Single-pass type I membrane protein {ECO:0000269|PubMed:10900005}. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
|
| Top Pathways |
Lysosome
|