IGF2R

Gene Symbol IGF2R
Entrez Gene 3482
Alt Symbol CD222, CIMPR, M6P-R, MPR1, MPRI
Species Human
Gene Type protein-coding
Description insulin-like growth factor 2 receptor
Other Description 300 kDa mannose 6-phosphate receptor|CI Man-6-P receptor|CI-MPR|IGF-II receptor|M6P/IGF2 receptor|M6P/IGF2R|M6PR|MPR 300|cation-independent mannose-6 phosphate receptor|cation-independent mannose-6-phosphate receptor|insulin-like growth factor II receptor
Swissprots P11717 Q96PT5 Q7Z7G9
Accessions AAF16870 AAK56918 AAL04402 AAP37954 CAA58672 CAA58673 CAA58674 CAA58675 CAA62977 EAW47607 P11717 AB209668 BAD92905 AK300848 BAG62499 BC172256 AAI72256 J03528 AAA59866 S80783 AAB35664 S80785 AAB35665 S80797 AAD14337 Y00285 CAA68395 XR_942419 NM_000876 NP_000867
Function Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. {ECO:0000269|PubMed:10900005}.
Subcellular Location Lysosome membrane {ECO:0000269|PubMed:10900005}; Single-pass type I membrane protein {ECO:0000269|PubMed:10900005}. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Top Pathways Lysosome

IGF-II Receptor/CI-M6PR (D3V8C) Rabbit mAb - 14364 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3V8C
Western blot analysis of extracts from various cells using IGF-II Receptor/CI-M6PR (D3V8C) Rabbit mAb.

IGF-II Receptor/CI-M6PR Antibody - 12871 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

IGF-IIR (H-300) - sc-25462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IGF-IIR (H-300): sc-25462. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colo-rectal cancer tissue showing cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

IGF-IIR (H-20) - sc-14408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IGF-IIR (K-21) - sc-14413 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IGF-IIR (K-21): sc-14413. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

IGF-IIR (C-15) - sc-14410 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IGF-IIR (C-15): sc-14410. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing membrane localization.

IGF-IIR (2G11) - sc-53146 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-M6PR (cation independent) (phospho S2409) antibody - ab138453 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-M6PR (cation independent) (phospho S2409) antibody (ab138453) at 1/500 dilution + Extracts from COS7 cells treated with UV for 15 minutes.

Anti-M6PR (cation independent) antibody - ab76281 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-M6PR (cation independent) antibody - ab61774 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61774 at 1/50 - 1/100 dilution staining Mannose 6 Phosphate (Cation independent) in human lung carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-M6PR (cation independent) antibody [EP6598] - ab180950 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP6598
All lanes : Anti-M6PR (cation independent) antibody [EP6598] (ab180950) at 1/2000 dilutionLane 1 : Jurkat cell lysateLane 2 : Human fetal kidney lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-M6PR (cation independent) antibody [EPR6599] - Lysosome Membrane Marker - ab124767 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6599
All lanes : Anti-M6PR (cation independent) antibody [EPR6599] - Lysosome Membrane Marker (ab124767) at 1/50000 dilutionLane 1 : Jurkat cell lysateLane 2 : 293T cell lysateLane 3 : Caco-2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-M6PR (cation independent) antibody [EPR6599] - Lysosome Membrane Marker (Alexa Fluor® 488) - ab184807 from Abcam

Prices $431.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6599
ab184807 staining Mannose-6-phosphate receptor in HeLa cells. The cells were fixed with 4% PFA (10min) and then blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1%PBS-Tween for 1h. The cells were then incubated with ab184807 at a working dilution of 1 in 100 overnight at +4°C (shown in green). AlexaFluor®350 WGA was used at a 1/200 dilution and incubated for 1h with the cells, to label plasma membranes (shown in blue). Nuclear DNA was labelled in red with 1.25 μM DRAQ5™ (ab108410).

Anti-M6PR (cation independent) antibody [EPR6599] - Lysosome Membrane Marker (Alexa Fluor® 568) - ab202535 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6599
ab202535 staining M6PR in Caco-2 cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab202535 at 1/100 dilution (pseudocolored in green) and ab195884, Rat monoclonal [YOL1/34] to Tubulin (Alexa Fluor® 647), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-M6PR (cation independent) antibody [MEM-238] - ab8093 from Abcam

Prices $400.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-238
ab8093 at 5µg/ml staining human HEK cells by immunocytochemistry. The cells were fixed with paraformaldehyde and incubated with the antibody for 1 hour. Bound antibody was detected using a goat anti-mouse IgG Alexa-Fluor ® 568. In the confocal image ab8093 labelling in red shows a distribution consistent with the location of the trans-Golgi network and lysosomes. Blue nuclear counterstain is present. This image is courtesy of an Abreview submitted by Randal Moldrich on 31 March 2006.See Abreview

Anti-M6PR (cation independent) antibody [MEM-238] (Alexa Fluor® 647) - ab187589 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-238

Anti-M6PR (cation independent) antibody [MEM-238] (Allophycocyanin) - ab77023 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-238

Anti-M6PR (cation independent) antibody [MEM-238] (FITC) - ab58841 from Abcam

Prices $193.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-238
ab58841 staining Mannose 6 Phosphate Receptor in a Human cell line by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with 0.5% NP-40 + 1% BSA in PBS and blocked with 1% BSA for 10 minutes at 25°C. Samples were incubated with primary antibody (1/50 in 0.5% NP-40 + 1% BSA in PBS) for 1 hour at 25°C.See Abreview

Anti-M6PR (cation independent) antibody [MEM-238] (FITC) - ab33389 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MEM-238
ab33389 staining human peripheral blood monocytes, following membrane permeablisation.

Anti-M6PR (cation independent) antibody [MEM-238] (Phycoerythrin) - ab77135 from Abcam

Prices $186.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-238

Anti-M6PR (cation independent) antibody - Lysosome Membrane Marker - ab12894 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HeLa cells labelled with anti-mannose-6-phosphate receptor (ab12894). ab12894 was used at a working concentration of 4µg/ml. The arrows indicate the perinuclear location of the mannose-6-phosphate receptor in the late endosomes. In the final panel DAPI is pseudo-coloured red, while the mannose-6-phosphate receptor is in green.

Anti-IGF2R / CD222 Antibody (aa2441-2490) IHC-plus™ - LS-B5653 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IGF2R antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5653 concentration 10 ug/ml.

Anti-IGF2R / CD222 Antibody (Extracellular Domain) IHC-plus™ - LS-B2351 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Anti-IGF2R antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2351 concentration 10 ug/ml.

Anti-IGF2R / CD222 Antibody (C-Terminus, clone EPR6599) IHC-plus™ - LS-B6310 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6599
Anti-IGF2R antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6310 dilution 1:50.

Anti-IGF2R / CD222 Antibody (aa2475-2491) - LS-C313287 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IGF2R / CD222 antibody. IHC(P): Human Intestinal Cancer Tissue.
Search more