IGF2R

Gene Symbol	IGF2R
Entrez Gene	3482
Alt Symbol	CD222, CIMPR, M6P-R, MPR1, MPRI
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor 2 receptor
Other Description	300 kDa mannose 6-phosphate receptor|CI Man-6-P receptor|CI-MPR|IGF-II receptor|M6P/IGF2 receptor|M6P/IGF2R|M6PR|MPR 300|cation-independent mannose-6 phosphate receptor|cation-independent mannose-6-phosphate receptor|insulin-like growth factor II receptor
Swissprots	P11717 Q96PT5 Q7Z7G9
Accessions	AAF16870 AAK56918 AAL04402 AAP37954 CAA58672 CAA58673 CAA58674 CAA58675 CAA62977 EAW47607 P11717 AB209668 BAD92905 AK300848 BAG62499 BC172256 AAI72256 J03528 AAA59866 S80783 AAB35664 S80785 AAB35665 S80797 AAD14337 Y00285 CAA68395 XR_942419 NM_000876 NP_000867
Function	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. {ECO:0000269|PubMed:10900005}.
Subcellular Location	Lysosome membrane {ECO:0000269|PubMed:10900005}; Single-pass type I membrane protein {ECO:0000269|PubMed:10900005}. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human M6PR (cation independent) peptide - ab13210 from Abcam Category Peptide

Human M6PR (cation independent) protein fragment - ab92245 from Abcam Category Protein Source E. coli Species Human

M6PR (cation independent) peptide - ab169957 from Abcam Category Peptide

IGF-II R/Mannose 6 Phosphate Receptor (Cation independent) Partial Recombinant Protein - H00003482-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human IGF-II R, CF - 2447-GR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser1510-Phe2108, with a C-terminal 6-His tag

Recombinant Human IGF-II R (aa 43-1365), CF - 6418-GR-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Gln41-Asp1365, with a C-terminal 6-His tag

Recombinant human Cation-independent mannose-6-phosphate receptor (OPCA00750) - OPCA00750 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human IGF2R Protein - abx067237 from Abbexa Category Protein Source E.coli Species Human

CD222 / IGF2R - H00003482-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD222 / IGF2R - H00003482-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human IGF2R, His-tagged - IGF2R-29238TH from Creative Biomart Category Protein Source E. coli

Recombinant Human IGF2R, His-tagged - IGF2R-677H from Creative Biomart Category Protein Source CHO Cells

Recombinant Human IGF2R, His-tagged - IGF2R-611H from Creative Biomart Category Protein Source Mouse NSO Cells

Recombinant Human IGF2R - IGF2R-239H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Insulin-Like Growth Factor 2 Receptor - IGF2R-619H from Creative Biomart Category Protein Source Produced recombinantlyin E. coli. Species Human

Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R) - RPB629Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R) - RPB629Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R) - RPB629Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

IGF-2R (F2480) Peptide - BS1755P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Insulin Like Growth Factor 2 Receptor (IGF2R) - RPB629Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Cation-independent mannose-6-phosphate receptor(IGF2R) ,partial - CSB-YP011093HU CSB-EP011093HU CSB-BP011093HU CSB-MP011093HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human IGF-II R (aa 43-1365) Protein, CF - 6418-GR from R&D Systems Category Protein Prices $339.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Gln41-Asp1365, with a C-terminal 6-His tag Species Human

Recombinant Human IGF-II R Protein, CF - 2447-GR from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Ser1510-Phe2108, with a C-terminal 6-His tag Species Human

Cation-independent mannose-6-phosphate receptor - RPC140277 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

CD222 Blocking Peptide - abx161891 from Abbexa Category Peptide Species Human, Mouse, Bovine

Search more