Gene Symbol | IGF2R |
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Entrez Gene | 3482 |
Alt Symbol | CD222, CIMPR, M6P-R, MPR1, MPRI |
Species | Human |
Gene Type | protein-coding |
Description | insulin-like growth factor 2 receptor |
Other Description | 300 kDa mannose 6-phosphate receptor|CI Man-6-P receptor|CI-MPR|IGF-II receptor|M6P/IGF2 receptor|M6P/IGF2R|M6PR|MPR 300|cation-independent mannose-6 phosphate receptor|cation-independent mannose-6-phosphate receptor|insulin-like growth factor II receptor |
Swissprots | P11717 Q96PT5 Q7Z7G9 |
Accessions | AAF16870 AAK56918 AAL04402 AAP37954 CAA58672 CAA58673 CAA58674 CAA58675 CAA62977 EAW47607 P11717 AB209668 BAD92905 AK300848 BAG62499 BC172256 AAI72256 J03528 AAA59866 S80783 AAB35664 S80785 AAB35665 S80797 AAD14337 Y00285 CAA68395 XR_942419 NM_000876 NP_000867 |
Function | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. {ECO:0000269|PubMed:10900005}. |
Subcellular Location | Lysosome membrane {ECO:0000269|PubMed:10900005}; Single-pass type I membrane protein {ECO:0000269|PubMed:10900005}. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface. |
Top Pathways | Lysosome |
IGF-IIR CRISPR/Cas9 KO Plasmid (h) - sc-401697 from Santa Cruz Biotechnology
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IGF-IIR HDR Plasmid (h) - sc-401697-HDR from Santa Cruz Biotechnology
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IGF-IIR Double Nickase Plasmid (h) - sc-401697-NIC from Santa Cruz Biotechnology
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IGF-IIR Double Nickase Plasmid (h2) - sc-401697-NIC-2 from Santa Cruz Biotechnology
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IGF-IIR CRISPR Activation Plasmid (h) - sc-401697-ACT from Santa Cruz Biotechnology
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IGF-IIR CRISPR Activation Plasmid (h2) - sc-401697-ACT-2 from Santa Cruz Biotechnology
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IGF-IIR Lentiviral Activation Particles (h) - sc-401697-LAC from Santa Cruz Biotechnology
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IGF-IIR Lentiviral Activation Particles (h2) - sc-401697-LAC-2 from Santa Cruz Biotechnology
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IGF-IIR siRNA (h) - sc-37118 from Santa Cruz Biotechnology
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IGF-IIR shRNA Plasmid (h) - sc-37118-SH from Santa Cruz Biotechnology
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IGF-IIR shRNA (h) Lentiviral Particles - sc-37118-V from Santa Cruz Biotechnology
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IGF-II R/Mannose 6 Phosphate Receptor (Cation independent) RNAi - H00003482-R03 from Novus Biologicals
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MISSION® esiRNA - EHU028581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10518 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10518 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09250 from Sigma-Aldrich
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IGF2R siRNA (Human) - CRH2353 from Cohesion Biosciences
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IGF2R - MBS8227724 from MyBioSource
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shRNA set against Human IGF2R (NM_000876.2) - SHH317505 from Creative biogene
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shRNA set against Human IGF2R(NM_000876.2) - SHL168178 from Creative biogene
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Human IGF2R siRNA - orb262855 from Biorbyt
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IGF2R shRNA Plasmid (Human) - CHH2353 from Cohesion Biosciences
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IGF2R miRNA 3'UTR clone - MiUTR1H-04837 from Creative biogene
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