IGF2R

Gene Symbol IGF2R
Entrez Gene 3482
Alt Symbol CD222, CIMPR, M6P-R, MPR1, MPRI
Species Human
Gene Type protein-coding
Description insulin-like growth factor 2 receptor
Other Description 300 kDa mannose 6-phosphate receptor|CI Man-6-P receptor|CI-MPR|IGF-II receptor|M6P/IGF2 receptor|M6P/IGF2R|M6PR|MPR 300|cation-independent mannose-6 phosphate receptor|cation-independent mannose-6-phosphate receptor|insulin-like growth factor II receptor
Swissprots P11717 Q96PT5 Q7Z7G9
Accessions AAF16870 AAK56918 AAL04402 AAP37954 CAA58672 CAA58673 CAA58674 CAA58675 CAA62977 EAW47607 P11717 AB209668 BAD92905 AK300848 BAG62499 BC172256 AAI72256 J03528 AAA59866 S80783 AAB35664 S80785 AAB35665 S80797 AAD14337 Y00285 CAA68395 XR_942419 NM_000876 NP_000867
Function Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. {ECO:0000269|PubMed:10900005}.
Subcellular Location Lysosome membrane {ECO:0000269|PubMed:10900005}; Single-pass type I membrane protein {ECO:0000269|PubMed:10900005}. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Top Pathways Lysosome

IGF-IIR CRISPR/Cas9 KO Plasmid (h) - sc-401697 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF-IIR HDR Plasmid (h) - sc-401697-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF-IIR Double Nickase Plasmid (h) - sc-401697-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF-IIR Double Nickase Plasmid (h2) - sc-401697-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF-IIR CRISPR Activation Plasmid (h) - sc-401697-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF-IIR CRISPR Activation Plasmid (h2) - sc-401697-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF-IIR Lentiviral Activation Particles (h) - sc-401697-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF-IIR Lentiviral Activation Particles (h2) - sc-401697-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGF-IIR siRNA (h) - sc-37118 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IGF-IIR shRNA Plasmid (h) - sc-37118-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IGF-IIR shRNA (h) Lentiviral Particles - sc-37118-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IGF-II R/Mannose 6 Phosphate Receptor (Cation independent) RNAi - H00003482-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU028581 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10518 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10518 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09250 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09250

IGF2R siRNA (Human) - CRH2353 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IGF2R - MBS8227724 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IGF2R (NM_000876.2) - SHH317505 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IGF2R(NM_000876.2) - SHL168178 from Creative biogene

Category siRNA
Species Reactivities Human

Human IGF2R siRNA - orb262855 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IGF2R shRNA Plasmid (Human) - CHH2353 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IGF2R miRNA 3'UTR clone - MiUTR1H-04837 from Creative biogene

Species Reactivities Human
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