SUV39H1

Gene Symbol	SUV39H1
Entrez Gene	6839
Alt Symbol	H3-K9-HMTase 1, KMT1A, MG44, SUV39H
Species	Human
Gene Type	protein-coding
Description	suppressor of variegation 3-9 homolog 1 (Drosophila)
Other Description	Su(var)3-9 homolog 1|histone H3-K9 methyltransferase 1|histone-lysine N-methyltransferase SUV39H1|histone-lysine N-methyltransferase, H3 lysine-9 specific 1|lysine N-methyltransferase 1A|position-effect variegation 3-9 homolog
Swissprots	Q6FHK6 Q53G60 B4DST0 O43463 B2R6E8
Accessions	CAA03483 EAW50756 EAW50757 O43463 AF019968 AAB92224 AF075109 AK223071 BAD96791 AK297566 BAG59958 AK298233 BAG60502 AK299900 BAG61742 AK312547 BAG35445 AW327567 BC006238 AAH06238 BG024540 CR541746 CAG46546 DQ892608 ABM83534 DQ895848 ABM86774 L08238 AAA59592 NM_001282166 NP_001269095 NM_003173 NP_003164
Function	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component
Subcellular Location	Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SUV39H1 (D11B6) Rabbit mAb - 8729 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D11B6

SUV39H1 Histone Methyltransferase Antibody - 2991 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

SUV39H1 (C-10) - sc-377112 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SUV39H1 (44.1) - sc-23961 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SUV39H1 (C-14) - sc-13608 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SUV39H1 (H-55) - sc-25366 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SUV39H1 (V-20) - sc-31727 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-KMT1A / SUV39H1 antibody - ab38637 from Abcam Prices $394.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-KMT1A / SUV39H1 antibody - ab110901 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KMT1A / SUV39H1 antibody [42AT239.96.72] - ab3659 from Abcam Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 42AT239.96.72

Anti-KMT1A / SUV39H1 antibody [44.1] - ChIP Grade - ab12405 from Abcam Prices $387.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 44.1

Anti-KMT1A / SUV39H1 antibody [EPR4960(2)] - ab124999 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4960(2)

Anti-SUV39H1 Antibody (aa78-108, AP) - LS-C270757 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUV39H1 Antibody (aa78-108, FITC) - LS-C270760 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUV39H1 Antibody (aa78-108, Azide-free, HRP) - LS-C270761 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUV39H1 Antibody (aa78-108, PE) - LS-C270762 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUV39H1 Antibody (N-Terminus, AP) - LS-C283247 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SUV39H1 Antibody (N-Terminus, Biotin) - LS-C283248 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SUV39H1 Antibody (N-Terminus, APC) - LS-C283249 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SUV39H1 Antibody (N-Terminus, FITC) - LS-C283251 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SUV39H1 Antibody (N-Terminus, PE) - LS-C283250 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SUV39H1 Antibody (N-Terminus, Azide-free, HRP) - LS-C283252 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-SUV39H1 Antibody (N-Terminus, APC) - LS-C283253 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUV39H1 Antibody (N-Terminus, AP) - LS-C283254 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SUV39H1 Antibody (aa108-157) - LS-C109667 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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