| Gene Symbol |
TREML2
|
| Entrez Gene |
79865
|
| Alt Symbol |
C6orf76, TLT-2, TLT2, dJ238O23.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
triggering receptor expressed on myeloid cells-like 2
|
| Other Description |
trem-like transcript 2 protein|triggering receptor expressed on myeloid cells-like protein 2
|
| Swissprots |
Q08AP9 Q9H8E9 Q08AP8 Q5T2D2 Q8IWY0
|
| Accessions |
EAX04035 EAX04036 Q5T2D2 AF534824 AAO15022 AJ420509 AK023755 BAB14668 AY358171 AAQ88538 BC125078 AAI25079 BC125079 AAI25080 XM_011514917 XP_011513219 NM_024807 NP_079083
|
| Function |
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. {ECO:0000269|PubMed:12645956, ECO:0000269|PubMed:18650384}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. {ECO:0000269|PubMed:12645956, ECO:0000269|PubMed:18650384}.
|
![Western Blot: TREML2 Overexpression Lysate (Adult Normal) [NBP2-06287] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TREML2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6653_TREML2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06287-img0001.jpg)