Gene Symbol | TREML2 |
---|---|
Entrez Gene | 79865 |
Alt Symbol | C6orf76, TLT-2, TLT2, dJ238O23.1 |
Species | Human |
Gene Type | protein-coding |
Description | triggering receptor expressed on myeloid cells-like 2 |
Other Description | trem-like transcript 2 protein|triggering receptor expressed on myeloid cells-like protein 2 |
Swissprots | Q08AP9 Q9H8E9 Q08AP8 Q5T2D2 Q8IWY0 |
Accessions | EAX04035 EAX04036 Q5T2D2 AF534824 AAO15022 AJ420509 AK023755 BAB14668 AY358171 AAQ88538 BC125078 AAI25079 BC125079 AAI25080 XM_011514917 XP_011513219 NM_024807 NP_079083 |
Function | Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. {ECO:0000269|PubMed:12645956, ECO:0000269|PubMed:18650384}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Tissue Specificity | Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. {ECO:0000269|PubMed:12645956, ECO:0000269|PubMed:18650384}. |