| Gene Symbol |
UBD
|
| Entrez Gene |
10537
|
| Alt Symbol |
FAT10, GABBR1, UBD-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin D
|
| Other Description |
diubiquitin|ubiquitin-like protein FAT10
|
| Swissprots |
O15205 Q5STL2 B0UZT6 Q96EC7 Q5SUK2
|
| Accessions |
CAA21458 EAX03201 O15205 AA878968 AF123050 AAD52982 AK311914 BAG34855 BC012472 AAH12472 CB111380 DB181897 DQ894624 ABM85550 Y12653 CAA73200 NM_006398 NP_006389
|
| Function |
Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:19033385}. Cytoplasm {ECO:0000250}. Note=Accumulates in aggresomes under proteasome inhibition conditions.
|
| Tissue Specificity |
Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland. {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:9368598}.
|