UBD

Gene Symbol UBD
Entrez Gene 10537
Alt Symbol FAT10, GABBR1, UBD-3
Species Human
Gene Type protein-coding
Description ubiquitin D
Other Description diubiquitin|ubiquitin-like protein FAT10
Swissprots O15205 Q5STL2 B0UZT6 Q96EC7 Q5SUK2
Accessions CAA21458 EAX03201 O15205 AA878968 AF123050 AAD52982 AK311914 BAG34855 BC012472 AAH12472 CB111380 DB181897 DQ894624 ABM85550 Y12653 CAA73200 NM_006398 NP_006389
Function Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization
Subcellular Location Nucleus {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:19033385}. Cytoplasm {ECO:0000250}. Note=Accumulates in aggresomes under proteasome inhibition conditions.
Tissue Specificity Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland. {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:9368598}.

FAT10 (A-8) - sc-393630 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAT10 (A-8): sc-393630. Western blot analysis of FAT10 expression in non-transfected: sc-117752 (A) and human FAT10 transfected: sc-113806 (B) 293T whole cell lysates.

FAT10 (E-16) - sc-51081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FAT10 (E-16): sc-51081. Western blot analysis of human recombinant FAT10 fusion protein.

FAT10 (FL-165) - sc-67203 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAT10 (FL-165): sc-67203. Western blot analysis of FAT10 expression in non-transfected: sc-117752 (A) and human FAT10 transfected: sc-113806 (B) 293T whole cell lysates.

FAT10 (G-5) - sc-133199 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAT10 (G-5): sc-133199. Western blot analysis of FAT10 expression in non-transfected: sc-117752 (A) and human FAT10 transfected: sc-113806 (B) 293T whole cell lysates.

FAT10 (I-16) - sc-51082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FAT10 (I-16): sc-51082. Western blot analysis of human recombinant FAT10 fusion protein.

FAT10 (R-161) - sc-67202 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

FAT10 (T-18) - sc-51086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AT10 (T-18): sc-51086. Western blot analysis of human recombinant FAT10 (A) and mouse recombinant FAT10 (B) fusion proteins.

Anti-Poly-ubiquitin (linkage specific K48) antibody [1001C] - ab190061 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 1001C
All lanes : Anti-Poly-ubiquitin (linkage specific K48) antibody [1001C] (ab190061) at 0.5 µg/mlLane 1 : Recombinant diubiquitin M1 linkageLane 2 : Recombinant diubiquitin K6 linkageLane 3 : Recombinant diubiquitin K11 linkageLane 4 : Recombinant diubiquitin K27 linkageLane 5 : Recombinant diubiquitin K29 linkageLane 6 : Recombinant diubiquitin K33 linkageLane 7 : Recombinant diubiquitin K48 linkageLane 8 : Recombinant diubiquitin K63 linkageLysates/proteins at 0.025 µg per lane.Secondaryanti-rabbit HRP (upper image); anti-mouse HRP (lower image) at 1/2000 dilutionA single band of appropriate size was detected only in the K48-linked diubiquitin lane.

Anti-Ubiquitin D antibody - ab197179 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-Ubiquitin D antibody (ab197179) at 1/500 dilution + HepG2 cell lysate

Anti-Ubiquitin D antibody - ab168680 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Ubiquitin D antibody (ab168680) at 1 µg/mlLane 1 : Diubiquitin transfected 293T lysateLane 2 : Non-transfected 293T lysate Lysates/proteins at 15 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-Ubiquitin D antibody - ab195428 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Ubiquitin D antibody - ab43773 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal

Anti-Ubiquitin D antibody - ab192581 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Ubiquitin D antibody [EPR4370] - ab134077 from Abcam

Prices $99.00, $379.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4370
Immunohistochemical analysis of paraffin embedded Human kidney tissue labelling Ubiquitin D with ab134077 at a dilution of 1/50.

Anti-FAT10 / UBD Antibody (aa120-153, AP) - LS-C257064 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (aa120-153, FITC) - LS-C257066 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (aa120-153, APC) - LS-C257065 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (aa120-153, Azide-free, HRP) - LS-C257067 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (aa120-153, PE) - LS-C257068 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (aa120-153, Biotin) - LS-C257080 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (aa1-165, Biotin) - LS-C300406 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (aa1-165, FITC) - LS-C303257 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (aa123-153) - LS-C321296 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody - LS-C341638 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FAT10 / UBD Antibody (Internal) - LS-C336291 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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