UBD

Gene Symbol UBD
Entrez Gene 10537
Alt Symbol FAT10, GABBR1, UBD-3
Species Human
Gene Type protein-coding
Description ubiquitin D
Other Description diubiquitin|ubiquitin-like protein FAT10
Swissprots O15205 Q5STL2 B0UZT6 Q96EC7 Q5SUK2
Accessions CAA21458 EAX03201 O15205 AA878968 AF123050 AAD52982 AK311914 BAG34855 BC012472 AAH12472 CB111380 DB181897 DQ894624 ABM85550 Y12653 CAA73200 NM_006398 NP_006389
Function Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization
Subcellular Location Nucleus {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:19033385}. Cytoplasm {ECO:0000250}. Note=Accumulates in aggresomes under proteasome inhibition conditions.
Tissue Specificity Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland. {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:9368598}.

FAT10 CRISPR/Cas9 KO Plasmid (h) - sc-402682 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAT10 HDR Plasmid (h) - sc-402682-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAT10 Double Nickase Plasmid (h) - sc-402682-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAT10 Double Nickase Plasmid (h2) - sc-402682-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAT10 CRISPR Activation Plasmid (h) - sc-402682-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAT10 CRISPR Activation Plasmid (h2) - sc-402682-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAT10 Lentiviral Activation Particles (h) - sc-402682-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAT10 Lentiviral Activation Particles (h2) - sc-402682-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FAT10 siRNA (h) - sc-60627 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FAT10 shRNA Plasmid (h) - sc-60627-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FAT10 shRNA (h) Lentiviral Particles - sc-60627-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN22351 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22351 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01285 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01285

UBD siRNA (Human) - CRH7162 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBD - MBS8204446 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UBD (NM_006398.3) - SHH438816 from Creative biogene

Category siRNA
Species Reactivities Human

UBD shRNA Plasmid (Human) - CHH7162 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UBD miRNA 3'UTR clone - MiUTR3H-08176 from Creative biogene

Species Reactivities Human
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